Chiara Rosso

TL;DR: Current evidence linking obesity, NAFLD and liver cancer is summarized, its clinical impact is discussed, and the main mechanisms underlying this complex relationship are described.

TL;DR: Increased plasma AA concentrations were observed mainly in subjects with obesity and NAFLD, likely as a consequence of increased IR and protein catabolism, and the GSG‐index is a possible marker of severity of liver disease independent of body mass index.

TL;DR: The role of bile acids and the gut microbiome in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) was investigated in a cohort of Caucasian patients with biopsy-proven NAFLD, lean healthy controls, and experimental murine models as mentioned in this paper.

TL;DR: The MBOat7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.

TL;DR: Analysis of gene expression during human NAFLD progression provides insights into the pathophysiology of progressive fibrosing steatohepatitis, and proof of principle that transcriptomic changes represent potentially tractable and clinically relevant markers of disease progression is provided.