C
Ching Wei Luo
Researcher at National Yang-Ming University
Publications - 35
Citations - 2430
Ching Wei Luo is an academic researcher from National Yang-Ming University. The author has contributed to research in topics: Receptor & Signal transduction. The author has an hindex of 16, co-authored 34 publications receiving 2260 citations. Previous affiliations of Ching Wei Luo include National Taiwan University & Stanford University.
Papers
More filters
Journal ArticleDOI
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake
Jian Zhang,Pei-Gen Ren,Orna Avsian-Kretchmer,Ching Wei Luo,Rami Rauch,Cynthia Klein,Aaron J. W. Hsueh +6 more
TL;DR: Contrary to the appetite-stimulating effects of ghrelin, treatment of rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body-weight gain.
Journal ArticleDOI
Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
Ching Wei Luo,Elizabeth M. Dewey,Satoko Sudo,John Ewer,Sheau Yu Hsu,Hans-Willi Honegger,Aaron J. W. Hsueh +6 more
TL;DR: It is shown that bursicon, to the authors' knowledge the first heterodimeric cystine knot hormone found in insects, consists of two proteins encoded by the genes burs and pburs (partner of burs).
Journal ArticleDOI
Neonatal Lethality of LGR5 Null Mice Is Associated with Ankyloglossia and Gastrointestinal Distension
Hiroki Morita,Sabine Mazerbourg,Donna M. Bouley,Ching Wei Luo,Kazuhiro Kawamura,Yoshimitsu Kuwabara,Helene Baribault,Hui Tian,Aaron J. W. Hsueh +8 more
TL;DR: The observed ankyloglossia phenotype provides a model for understanding the genetic basis of this craniofacial defect in humans and an opportunity to elucidate the physiological role of the LGR5 signaling system during embryonic development.
Journal ArticleDOI
Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses.
TL;DR: The present approach provides a genomic paradigm for matching paralogous polypeptide ligands with a limited number of evolutionarily related receptors capable of activating specific downstream Smad proteins.
Journal ArticleDOI
Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors.
TL;DR: In cultured rat granulosa cells obtained from early antral follicles, treatment with STC1 suppressed FSH-stimulated progesterone biosynthesis with minimal effects on estradiol and cAMP production and the present demonstration of receptor binding and the specific actions of STC2 suggest the existence of a follicular paracrine system in which theca cell-derived STC 1 dampens the gonadotropin stimulation of granULosa cell differentiation.