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Donna M. Bouley
Researcher at Stanford University
Publications - 112
Citations - 9121
Donna M. Bouley is an academic researcher from Stanford University. The author has contributed to research in topics: Magnetic resonance imaging & Ultrasound. The author has an hindex of 46, co-authored 112 publications receiving 8022 citations. Previous affiliations of Donna M. Bouley include Brigham and Women's Hospital & Texas A&M University.
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Journal ArticleDOI
m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
Pedro J. Batista,Benoit Molinie,Jinkai Wang,Kun Qu,Jiajing Zhang,Lingjie Li,Donna M. Bouley,Ernesto Lujan,Bahareh Haddad,Kaveh Daneshvar,Ava C. Carter,Ryan A. Flynn,Chan Zhou,Kok-Seong Lim,Peter C. Dedon,Marius Wernig,Alan C. Mullen,Yi Xing,Cosmas Giallourakis,Howard Y. Chang +19 more
TL;DR: Mapping the m( 6)A methylome in mouse and human embryonic stem cells reveals the evolutionary conservation and function of m(6)A, a mark of transcriptome flexibility required for stem cells to differentiate to specific lineages.
Journal ArticleDOI
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
Petr Broz,Thomas Ruby,Kamila Belhocine,Donna M. Bouley,Nobuhiko Kayagaki,Vishva M. Dixit,Denise M. Monack +6 more
TL;DR: It is shown that non-canonical caspase-11 activation contributes to macrophage death during S. typhimurium infection, indicating that caspases-11-dependent cell death is detrimental to the host in the absence of caspasing-1-mediated innate immunity, resulting in extracellular replication of a facultative intracellular bacterial pathogen.
Journal Article
Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.
Theresa A. Banks,Barry T. Rouse,M. K. Kerley,Patrick Blair,V. L. Godfrey,Nelly A. Kuklin,Donna M. Bouley,Johnson Thomas,Sivadasan Kanangat,M. L. Mucenski +9 more
TL;DR: The utility of this mouse model as a system for understanding lymphoid organ development and its effects on immune responsiveness and the ability to reconstitute the lymphoid organs of severe combined immunodeficient mice is illustrated.
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Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
Denise A. Chan,Patrick D. Sutphin,Phuong Nguyen,Sandra Turcotte,Edwin W. Lai,Alice Banh,Gloria E. Reynolds,Jen-Tsan Chi,Jason Wu,David E. Solow-Cordero,Muriel Bonnet,Jack U. Flanagan,Donna M. Bouley,Edward E. Graves,William A. Denny,Michael P. Hay,Amato J. Giaccia +16 more
TL;DR: A screen identifies a drug that specifically kills glycolysis-dependent cancer cells by inhibiting glucose uptake and identifies a class of compounds, the 3-series, exemplified by STF-31, which selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells onGLUT1 for survival.
Journal ArticleDOI
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
Ioanna Papandreou,Nicholas C. Denko,Michael R. Olson,Heleen Van Melckebeke,Sofie Lust,Arvin B. Tam,David E. Solow-Cordero,Donna M. Bouley,Fritz Offner,Maho Niwa,Albert C. Koong +10 more
TL;DR: The identification of STF-083010, a novel small-molecule inhibitor of Ire1, supports the hypothesis that the Ire1-XBP1 axis is a promising target for anticancer therapy, especially in the context of MM.