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Guangwen Lu
Researcher at Sichuan University
Publications - 87
Citations - 7836
Guangwen Lu is an academic researcher from Sichuan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 29, co-authored 68 publications receiving 5485 citations. Previous affiliations of Guangwen Lu include Chinese Academy of Sciences.
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Journal ArticleDOI
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2.
Qihui Wang,Yanfang Zhang,Lili Wu,Sheng Niu,Sheng Niu,Chunli Song,Chunli Song,Zengyuan Zhang,Guangwen Lu,Chengpeng Qiao,Yu Hu,Yu Hu,Kwok-Yung Yuen,Qisheng Wang,Huan Zhou,Jinghua Yan,Jianxun Qi +16 more
TL;DR: The crystal structure of the C-terminal domain of SARS-CoV-2 (SARS- coV- 2-CTD) spike (S) protein in complex with human ACE2 (hACE2) is presented, which reveals a hACE2-binding mode similar overall to that observed for SARS -CoV.
Journal ArticleDOI
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Yuan Yuan,Duanfang Cao,Yanfang Zhang,Jun Ma,Jianxun Qi,Qihui Wang,Guangwen Lu,Ying Wu,Jinghua Yan,Yi Shi,Xinzheng Zhang,George F. Gao +11 more
TL;DR: High-resolution structures of the trimeric MERS- coV and SARS-CoV S proteins in its pre-fusion conformation are presented by single particle cryo-electron microscopy, demonstrating an inherently flexible RBD readily recognized by the receptor.
Journal ArticleDOI
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
Guangwen Lu,Yawei Hu,Qihui Wang,Jianxun Qi,Feng Gao,Feng Gao,Yan Li,Yanfang Zhang,Wei Zhang,Yuan Yuan,Yuan Yuan,Jinku Bao,Buchang Zhang,Yi Shi,Jinghua Yan,George F. Gao +15 more
TL;DR: The crystal structure of the receptor binding domain of the MERS-CoV spike protein, both free and bound to the receptor, was presented in this article, which revealed a core subdomain homologous to that of the SARS-coV spike proteins, and a unique strand-dominated external receptor binding motif that recognizes blades IV and V of the CD26 β-propeller.
Journal ArticleDOI
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
Jingyun Yang,Wei Wang,Zimin Chen,Shuaiyao Lu,Fanli Yang,Zhenfei Bi,Linlin Bao,Fei Mo,Xue Li,Yong Huang,Weiqi Hong,Yun Yang,Yuan Zhao,Fei Ye,Sheng Lin,Wei Deng,Hua Chen,Hong Lei,Ziqi Zhang,Min Luo,Hong Gao,Yue Zheng,Yanqiu Gong,Xiaohua Jiang,Yanfeng Xu,Qi Lv,Dan Li,Manni Wang,Fengdi Li,Shunyi Wang,Guanpeng Wang,Pin Yu,Yajin Qu,Li Yang,Hongxin Deng,Aiping Tong,Jiong Li,Z. H. Wang,Jinliang Yang,Guobo Shen,Zhiwei Zhao,Yuhua Li,Jingwen Luo,Hongqi Liu,Wenhai Yu,Mengli Yang,Jingwen Xu,Junbin Wang,Haiyan Li,Haixuan Wang,Dexuan Kuang,Panpan Lin,Zhengtao Hu,Wei Guo,Wei Cheng,Yanlin He,Xiangrong Song,Chong Chen,Zhihong Xue,Shaohua Yao,Lu Chen,Xuelei Ma,Siyuan Chen,Maling Gou,Weijin Huang,Youchun Wang,Changfa Fan,Zhixin Tian,Ming Shi,Fu-Sheng Wang,Lunzhi Dai,Min Wu,Gen Li,Guangyu Wang,Yong Peng,Zhiyong Qian,Canhua Huang,Johnson Y.N. Lau,Zhenglin Yang,Yuquan Wei,Xiaobo Cen,Xiaozhong Peng,Chuan Qin,Kang Zhang,Guangwen Lu,Xiawei Wei +85 more
TL;DR: It is shown that a recombinant vaccine that comprises residues 319–545 of the RBD of the spike protein induces a potent functional antibody response in immunized mice, rabbits and non-human primates as early as 7 or 14 days after the injection of a single vaccine dose.
Journal ArticleDOI
Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond.
TL;DR: The progress made in the past decade in understanding the cross-species transmission of SARS- coV and MERS-CoV is summarized by focusing on the features of the S protein, its receptor-binding characteristics, and the cleavage process involved in priming.