C
Chris A. Whitehouse
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 72
Citations - 5793
Chris A. Whitehouse is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Virus & Monkeypox virus. The author has an hindex of 31, co-authored 64 publications receiving 4608 citations. Previous affiliations of Chris A. Whitehouse include University of Kentucky & United States Geological Survey.
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Journal ArticleDOI
High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses.
Rajini Mudhasani,Krishna P. Kota,Cary Retterer,Julie P. Tran,Chris A. Whitehouse,Sina Bavari +5 more
TL;DR: High content image-based screening was developed as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus and to determine their mechanism of action and any possible deleterious effects on host cellular biology and demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals.
Journal ArticleDOI
Microbial water quality of the Georgian coastal zone of the Black Sea.
Nino Janelidze,E. Jaiani,Nino Lashkhi,A. Tskhvediani,Tamar Kokashvili,T. Gvarishvili,D. Jgenti,E. Mikashavidze,R. Diasamidze,S. Narodny,R. Obiso,Chris A. Whitehouse,Anwar Huq,Marina Tediashvili +13 more
TL;DR: Microbial indicators generally showed seasonal dependence, suggesting that temperature may influence bacterial dynamics in this environment, and no correlation was apparent between fecal pollution indicators and physical-chemical and aquatic microbial parameters, although there was significant relationships amongst the indicators themselves.
Journal ArticleDOI
Rapid and high-throughput pan-Orthopoxvirus detection and identification using PCR and mass spectrometry.
Mark W. Eshoo,Chris A. Whitehouse,Aysegul Nalca,Scott T. Zoll,Joseph A. Ecker,Thomas A. Hall,Thuy Trang D. Pennella,David D. Duncan,Anjali Desai,Emily Moradi,Karl Rudnick,Brian Libby,Raymond Ranken,Rangarajan Sampath,Steven A. Hofstadler,David J. Ecker,Lawrence B. Blyn +16 more
TL;DR: It is demonstrated that the assay can detect and identify a diverse collection of orthopoxviruses, provide sub-species information and characterize viruses from the blood of rabbitpox infected rabbits, and is sensitive at the stochastic limit of PCR.
Journal ArticleDOI
Prevalence of hypermucoid Klebsiella pneumoniae among wild-caught and captive vervet monkeys (Chlorocebus aethiops sabaeus) on the island of St. Kitts.
Chris A. Whitehouse,Natalie Keirstead,Justin K. Taylor,Jessica L. Reinhardt,Amy Beierschmitt +4 more
TL;DR: This is the first report of hypermucoid K. pneumoniae isolation from a wild population of nonhuman primates and represents a potential health risk to these animals, as well as to the humans who come in contact with them.
Journal Article
Epidemiology of invasive Klebsiella pneumoniae with hypermucoviscosity phenotype in a research colony of nonhuman primates.
TL;DR: Random amplified polymorphic DNA analysis on a subset of clinical isolates confirmed a high degree of genetic diversity between the samples, and PCR testing for 2 genes associated with HMV K. pneumoniae, rmpA and magA, suggested genetic variability in the samples.