C
Chris A. Whitehouse
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 72
Citations - 5793
Chris A. Whitehouse is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Virus & Monkeypox virus. The author has an hindex of 31, co-authored 64 publications receiving 4608 citations. Previous affiliations of Chris A. Whitehouse include University of Kentucky & United States Geological Survey.
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Journal ArticleDOI
Smallpox Vaccine Does Not Protect Macaques with AIDS from a Lethal Monkeypox Virus Challenge
Yvette Edghill Smith,Mike Bray,Chris A. Whitehouse,David Miller,Eric M. Mucker,Jody Manischewitz,Lisa R. King,Marjorie Robert Guroff,Anna Hryniewicz,David Venzon,Clement A. Meseda,Jerry P. Weir,Aysegul Nalca,Virginia Livingston,Jay Wells,Mark G. Lewis,John W. Huggins,Susan H. Zwiers,Hana Golding,Genoveffa Franchini +19 more
TL;DR: It is demonstrated that, although smallpox vaccination is safe in immunodeficient macaques when it is preceded by immunization with highly attenuated vaccinia strains, the macaques were not protected against lethal monkeypox virus challenge if their CD4(+) cell count was <300 cells/mm(3).
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Entry of Yersinia pestis into the Viable but Nonculturable State in a Low-Temperature Tap Water Microcosm
David R. Pawlowski,Daniel J. Metzger,Amy Raslawsky,Amy Howlett,Gretchen Siebert,Richard J. Karalus,Stephanie Garrett,Chris A. Whitehouse +7 more
TL;DR: In this paper, the authors showed that Y. pestis became nonculturable by normal laboratory methods after 21 days in a low-temperature tap water microcosm, but the cells remained viable by using a variety of criteria, including cellular membrane integrity, uptake and incorporation of radiolabeled amino acids, and protection of genomic DNA from DNase I digestion.
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A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus
TL;DR: Development of this simple and reliable screening method for discovering new antiviral compounds directed against CCHFV will potentially allow high-throughput screening for discovering additional antiviral drugs to combat this important public health threat.
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A Single Phosphorodiamidate Morpholino Oligomer Targeting VP24 Protects Rhesus Monkeys against Lethal Ebola Virus Infection
Travis K. Warren,Chris A. Whitehouse,Jay Wells,Lisa S. Welch,Alison E. Heald,Jay S. Charleston,Pete Sazani,St. Patrick Reid,Patrick L. Iversen,Sina Bavari +9 more
TL;DR: This study demonstrated that targeting a single protein was effective at conferring a significant survival benefit in an EBOV lethal primate model and suggested that VP24 is a promising target for the development of effective anti-EBOV countermeasures.
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Arbovirus detection in insect vectors by rapid, high-throughput pyrosequencing.
Kimberly A. Bishop-Lilly,Michael J. Turell,Kristin M Willner,Amy Butani,Nichole Nolan,Shannon M. Lentz,Arya Akmal,Al Mateczun,Trupti N. Brahmbhatt,Shanmuga Sozhamannan,Chris A. Whitehouse,Timothy D. Read +11 more
TL;DR: Dengue virus type 1 RNA was sufficiently concentrated in the mosquito that its detection was feasible using current high-throughput sequencing instrumentation, and some of the components of the mosquito microflora were identified on the basis of the sequence of expressed RNA.