C
Chris Galanos
Researcher at Max Planck Society
Publications - 176
Citations - 30451
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications receiving 29595 citations. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
A new method for the extraction of R lipopolysaccharides.
TL;DR: A method is described which is specific for the extraction of lipopolysaccharides from R form bacteria, which consists of aqueous phenol, chloroform and petroleum ether.
Journal ArticleDOI
Galactosamine-induced sensitization to the lethal effects of endotoxin.
TL;DR: The data so far suggests that the sensitization to lipopolysaccharide is related only to the early metabolic effects of the hexosamine, which is known to exhibit hepatotoxic activity inducing ultimate necrosis of the hepatocytes.
Journal ArticleDOI
CD14 is required for MyD88-independent LPS signaling
Zhengfan Jiang,Philippe Georgel,Xin Du,Louis Shamel,Sosathya Sovath,Suzanne Mudd,Michael Huber,Christoph Kalis,Simone Keck,Chris Galanos,Marina A. Freudenberg,Bruce Beutler +11 more
TL;DR: The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective responses to microbial inducers, and the data suggest that the TLR4–MD-2 complex distinguishes LPS chemotypes, but CD14 nullifies this distinction.