Michael Huber

TL;DR: Analysis of neutralization by the full complement of anti-HIV broadly neutralizing monoclonal antibodies now available reveals that certain combinations of antibodies should offer markedly more favourable coverage of the enormous diversity of global circulating viruses than others and these combinations might be sought in active or passive immunization regimes.

TL;DR: The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective responses to microbial inducers, and the data suggest that the TLR4–MD-2 complex distinguishes LPS chemotypes, but CD14 nullifies this distinction.

TL;DR: Escape mutant analysis showed that the activity of 2G12 was crucial for the in vivo effect of the neutralizing antibody cocktail, and underline both the potential and the limits of humoral immunity in controlling HIV-1 infection.

TL;DR: Evidence of viable tissue in the border zone of ischemia up to 48 h after stroke is furnished, while this viable peri-infarct tissue exhibits some potential for effective treatment of ischemic stroke.

TL;DR: It is demonstrated that monomeric IgE (mIgE) in the absence of antigen (Ag) stimulates multiple phosphorylation events in normal murine bone marrow-derived mast cells (BMMCs) and leads to a more potent production of cytokines than IgE + Ag.