C
Chris Kintner
Researcher at Salk Institute for Biological Studies
Publications - 119
Citations - 16929
Chris Kintner is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Xenopus & Notch signaling pathway. The author has an hindex of 70, co-authored 117 publications receiving 16240 citations. Previous affiliations of Chris Kintner include University of Oxford & Massachusetts Institute of Technology.
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Identification of neurogenin, a Vertebrate Neuronal Determination Gene
TL;DR: A novel, NeuroD-related bHLH protein, NEUROGENIN, whose expression precedes that of NeuroD in both mouse and Xenopus is described, suggesting that it functions as a vertebrate neuronal determination factor.
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Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.
Ajay B. Chitnis,Domingos Henrique,Julian Lewis,David Ish-Horowicz,Chris Kintner,Chris Kintner +5 more
TL;DR: Results indicate that the X-Delta-1 protein mediates lateral inhibition delivered by prospective neurons to adjacent cells, and that commitment to a neural fate in vertebrates is regulated by Delta-Notch signalling as in Drosophila.
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Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
Janet Heasman,Aaron Crawford,Kim Goldstone,Peggy Garner-Hamrick,Barry M. Gumbiner,Pierre D. McCrea,Chris Kintner,Chikako Yoshida Noro,Chris Wylie +8 more
TL;DR: Results show that beta-catenin has an important role in dorsal mesoderm induction and directly demonstrate the activity of a maternal mRNA in axis specification.
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A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
Hung Ying Kao,Peter Ordentlich,Peter Ordentlich,Peter Ordentlich,Naoko Koyano-Nakagawa,Zhenyu Tang,Zhenyu Tang,Michael Downes,Chris Kintner,Ronald M. Evans,Ronald M. Evans,Tom Kadesch,Tom Kadesch +12 more
TL;DR: The functional role for the SMRT/HDAC-1 complex in CBF1/RBP-Jkappa regulation reveals a novel genetic switch in which extracellular ligands control the status of critical nuclear cofactor complexes.
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Dll4, a novel Notch ligand expressed in arterial endothelium
John R. Shutter,Sheila Scully,Wei Fan,William G. Richards,Jan Kitajewski,Gisèle A. Deblandre,Chris Kintner,Kevin L. Stark +7 more
TL;DR: The cloning and characterization of a new member of the Delta family of Notch ligands, which is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding is reported.