C
Chris Wylie
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 36
Citations - 3425
Chris Wylie is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Xenopus & Blastula. The author has an hindex of 25, co-authored 36 publications receiving 3335 citations. Previous affiliations of Chris Wylie include University of Minnesota & University of Cambridge.
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Journal ArticleDOI
Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
Janet Heasman,Aaron Crawford,Kim Goldstone,Peggy Garner-Hamrick,Barry M. Gumbiner,Pierre D. McCrea,Chris Kintner,Chikako Yoshida Noro,Chris Wylie +8 more
TL;DR: Results show that beta-catenin has an important role in dorsal mesoderm induction and directly demonstrate the activity of a maternal mRNA in axis specification.
Journal ArticleDOI
βCatenin Signaling Activity Dissected in the Early Xenopus Embryo: A Novel Antisense Approach
TL;DR: The use of a novel antisense approach that allows for target depletion of protein to individual blastomeres and offers a rapid method for the functional analysis of both maternal and early zygotic gene products in Xenopus is reported.
Journal ArticleDOI
Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors
Matt Kofron,Teresa Demel,Jenny Xanthos,Jamie L. Lohr,Benjamin Sun,Hazel Sive,Shin Ichi Osada,Christopher V.E. Wright,Chris Wylie,Janet Heasman +9 more
TL;DR: It is concluded that mesoderm induction in Xenopus depends on a maternal transcription factor regulating these zygotic growth factors, as measured by the expression of mesodermal markers MyoD, cardiac actin, Xbra, Xwnt8 and alphaT4 globin.
Journal ArticleDOI
Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning.
TL;DR: Xklp1 is a novel Xenopus kinesin-like protein with a motor domain at the amino terminus, nuclear localization sequences in the stalk, and a putative zinc finger-like sequence in the tail that is nuclear during interphase and chromosomal during mitosis.
Book ChapterDOI
Primordial germ cell migration.
TL;DR: This study has revealed that germ cells link up with each other forming extensive networks during migration, and labels germ cells in whole-mount preparations with an antibody to the germ cell marker SSEA-1 reveal the spatial distribution of Germ cells in situ using confocal microscopy.