J
Janet Heasman
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 109
Citations - 10712
Janet Heasman is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Xenopus & Endoderm. The author has an hindex of 54, co-authored 109 publications receiving 10434 citations. Previous affiliations of Janet Heasman include St George's Hospital & University of Minnesota.
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Journal ArticleDOI
Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
Janet Heasman,Aaron Crawford,Kim Goldstone,Peggy Garner-Hamrick,Barry M. Gumbiner,Pierre D. McCrea,Chris Kintner,Chikako Yoshida Noro,Chris Wylie +8 more
TL;DR: Results show that beta-catenin has an important role in dorsal mesoderm induction and directly demonstrate the activity of a maternal mRNA in axis specification.
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Morpholino oligos: making sense of antisense?
TL;DR: The evidence so far suggests that, with careful controls, morpholinos provide a relatively simple and rapid method to study gene function.
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βCatenin Signaling Activity Dissected in the Early Xenopus Embryo: A Novel Antisense Approach
TL;DR: The use of a novel antisense approach that allows for target depletion of protein to individual blastomeres and offers a rapid method for the functional analysis of both maternal and early zygotic gene products in Xenopus is reported.
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Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.
Qinghua Tao,Chika Yokota,Helbert Puck,Matt Kofron,Bilge Birsoy,Dong Yan,Makoto Asashima,Christopher Wylie,Xinhua Lin,Janet Heasman +9 more
TL;DR: Three lines of evidence are provided that the pathway specifying the dorsal axis is activated extracellularly in Xenopus embryos and it is found that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling.
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The role of maternal VegT in establishing the primary germ layers in Xenopus embryos
Jian Zhang,Douglas W. Houston,Mary Lou King,Christopher J. Payne,Christopher Wylie,Janet Heasman +5 more
TL;DR: The results show that a single maternally expressed gene controls the patterning of the Xenopus blastula.