C
Chrissa A. Dwyer
Researcher at Isis Pharmaceuticals
Publications - 3
Citations - 90
Chrissa A. Dwyer is an academic researcher from Isis Pharmaceuticals. The author has contributed to research in topics: Oligonucleotide & Gene. The author has an hindex of 2, co-authored 3 publications receiving 12 citations.
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Journal ArticleDOI
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS
Tetsuya Nagata,Chrissa A. Dwyer,Kie Yoshida-Tanaka,Kensuke Ihara,Masaki Ohyagi,Hidetoshi Kaburagi,Haruka Miyata,Satoe Ebihara,Kotaro Yoshioka,Takashi Ishii,Kanjiro Miyata,Kenichi Miyata,Berit Powers,Tomoko Igari,Syunsuke Yamamoto,Naoto Arimura,Hideki Hirabayashi,Toshiki Uchihara,Rintaro Iwata Hara,Rintaro Iwata Hara,Takeshi Wada,C. Frank Bennett,Punit P. Seth,Frank Rigo,Takanori Yokota +24 more
TL;DR: In this article, DNA/RNA heteroduplex oligonucleotides conjugated to cholesterol or α-tocopherol at the 5′ end of the RNA strand reach the central nervous system (CNS) after subcutaneous or intravenous administration in mice and rats.
Journal ArticleDOI
Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides.
Mehran Nikan,Michael Tanowitz,Chrissa A. Dwyer,Michaela Jackson,Hans Gaus,Eric E. Swayze,Frank Rigo,Punit P. Seth,Thazha P. Prakash +8 more
TL;DR: Neurotensin-mediated targeted delivery represents a possible approach for enhancing potency of ASOs with diverse nucleic acid modifications.
Journal ArticleDOI
Systemic delivery of a DUX4-targeting antisense oligonucleotide to treat facioscapulohumeral muscular dystrophy
Linde F. Bouwman,Bianca den Hamer,Anita van den Heuvel,Marnix Franken,Michaela Jackson,Chrissa A. Dwyer,Stephen J. Tapscott,Stephen J. Tapscott,Frank Rigo,Silvère M. van der Maarel,Jessica C. de Greef +10 more
TL;DR: In this paper, a systemically delivered antisense oligonucleotide (ASO) targeting the DUX4 transcript was tested in vivo in ACTA1-MCM;FLExDUX4 mice that express Dux4 in skeletal muscles.