Hidetoshi Kaburagi

TL;DR: In this article, DNA/RNA heteroduplex oligonucleotides conjugated to cholesterol or α-tocopherol at the 5′ end of the RNA strand reach the central nervous system (CNS) after subcutaneous or intravenous administration in mice and rats.

TL;DR: This study provides important evidence for the contribution of TRPV1 to thermal hypersensitivity in neuropathic pain and establishes intrathecal AAV9-mediated gene delivery as an investigative and potentially therapeutic platform for the nervous system.

TL;DR: This proof‐of‐concept study demonstrated that intravenously injected angubindin‐1 increased the permeability of the blood–brain barrier and enabled transient delivery of subsequently administered antisense oligonucleotides into the mouse brain and spinal cord, leading to silencing of a target RNA without any overt adverse effects.

TL;DR: The study indicates that the application of BMSCs in a HC scaffold in the injured spinal cord directly promoted sensory nerve and rubrospinal tract regeneration, thus resulting in functional recovery.

TL;DR: It was concluded that women with distal radial fractures who were surgically treated showed lower grip strength and dynamic body balancing than those of controls, suggesting that measurements of grip strengthand dynamic body balance may be useful screening tools to assess future fracture risk.