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Rintaro Iwata Hara
Researcher at Tokyo University of Science
Publications - 26
Citations - 183
Rintaro Iwata Hara is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: RNA & Oligonucleotide. The author has an hindex of 6, co-authored 21 publications receiving 73 citations. Previous affiliations of Rintaro Iwata Hara include Tokyo Medical and Dental University.
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Journal ArticleDOI
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS
Tetsuya Nagata,Chrissa A. Dwyer,Kie Yoshida-Tanaka,Kensuke Ihara,Masaki Ohyagi,Hidetoshi Kaburagi,Haruka Miyata,Satoe Ebihara,Kotaro Yoshioka,Takashi Ishii,Kanjiro Miyata,Kenichi Miyata,Berit Powers,Tomoko Igari,Syunsuke Yamamoto,Naoto Arimura,Hideki Hirabayashi,Toshiki Uchihara,Rintaro Iwata Hara,Rintaro Iwata Hara,Takeshi Wada,C. Frank Bennett,Punit P. Seth,Frank Rigo,Takanori Yokota +24 more
TL;DR: In this article, DNA/RNA heteroduplex oligonucleotides conjugated to cholesterol or α-tocopherol at the 5′ end of the RNA strand reach the central nervous system (CNS) after subcutaneous or intravenous administration in mice and rats.
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Highly efficient silencing of microRNA by heteroduplex oligonucleotides.
Kotaro Yoshioka,Taiki Kunieda,Yutaro Asami,Huijia Guo,Haruka Miyata,Kie Yoshida-Tanaka,Yumiko Sujino,Wenying Piao,Hiroya Kuwahara,Kazutaka Nishina,Rintaro Iwata Hara,Tetsuya Nagata,Takeshi Wada,Satoshi Obika,Takanori Yokota +14 more
TL;DR: Heteroduplex oligonucleotide (HDO)-antimiR is designed as a new technology comprising an antimiR and its complementary RNA that binds targeted miRNA in vivo more efficiently and produces enhanced phenotypic effects in mice with upregulated expression of miRNA-targeting messenger RNAs.
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Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties
Rintaro Iwata Hara,Rintaro Iwata Hara,Tatsuya Saito,Tomoki Kogure,Yuka Hamamura,Naoki Uchiyama,Yohei Nukaga,Naoki Iwamoto,Takeshi Wada +8 more
TL;DR: It was demonstrated that there were significant differences between all-( Rp)- and all-( Sp)-PB-DNA in terms of the duplex-formation ability, nuclease resistance, and ribonuclease H (RNase H) activity.
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Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs.
TL;DR: Results suggest that ODAGal4 and ODGGal3 are useful because they could both stabilize the HDO and maintain RNase H activity of the gapmer, which is considered to be the main cause of RNA degradation in serum.
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Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio
TL;DR: ODAGals can serve as promising stabilizers or carriers of dsRNA-based drugs such as RNAi drugs as well as protect siRNAs with a low N/P ratio from cleavage by RNase A.