K
Kie Yoshida-Tanaka
Researcher at Tokyo Medical and Dental University
Publications - 17
Citations - 417
Kie Yoshida-Tanaka is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Gene silencing & Oligonucleotide. The author has an hindex of 7, co-authored 14 publications receiving 272 citations.
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Journal ArticleDOI
DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing
Kazutaka Nishina,Wenying Piao,Kie Yoshida-Tanaka,Yumiko Sujino,Tomoko Nishina,Tsuyoshi Yamamoto,Keiko Nitta,Kotaro Yoshioka,Hiroya Kuwahara,Hidenori Yasuhara,Takeshi Baba,Fumiko Ono,Kanjiro Miyata,Koichi Miyake,Punit P. Seth,Audrey Low,Masayuki Yoshida,C. Frank Bennett,Kazunori Kataoka,Hidehiro Mizusawa,Satoshi Obika,Takanori Yokota +21 more
TL;DR: A DNA/locked nucleotide acid gapmer duplex with an α-tocopherol-conjugated complementary RNA (Toc-HDO) is significantly more potent at reducing the expression of the targeted mRNA in liver compared with the parent single-stranded gapmer ASO.
Journal ArticleDOI
Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol.
Tomoko Nishina,Junna Numata,Kazutaka Nishina,Kie Yoshida-Tanaka,Keiko Nitta,Wenying Piao,Rintaro Iwata,Shingo Ito,Hiroya Kuwahara,Takeshi Wada,Hidehiro Mizusawa,Takanori Yokota +11 more
TL;DR: A new, effective LNA-DNA gapmer structure in which drug delivery system (DDS) molecules are bound to ASO with UNA sequences is identified in which the α-tocopherol–conjugated ASO showed high efficacy, with hepatic tropism, and was effective and safe for gene silencing in vivo.
Journal ArticleDOI
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS
Tetsuya Nagata,Chrissa A. Dwyer,Kie Yoshida-Tanaka,Kensuke Ihara,Masaki Ohyagi,Hidetoshi Kaburagi,Haruka Miyata,Satoe Ebihara,Kotaro Yoshioka,Takashi Ishii,Kanjiro Miyata,Kenichi Miyata,Berit Powers,Tomoko Igari,Syunsuke Yamamoto,Naoto Arimura,Hideki Hirabayashi,Toshiki Uchihara,Rintaro Iwata Hara,Rintaro Iwata Hara,Takeshi Wada,C. Frank Bennett,Punit P. Seth,Frank Rigo,Takanori Yokota +24 more
TL;DR: In this article, DNA/RNA heteroduplex oligonucleotides conjugated to cholesterol or α-tocopherol at the 5′ end of the RNA strand reach the central nervous system (CNS) after subcutaneous or intravenous administration in mice and rats.
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Intrathecal AAV Serotype 9-mediated Delivery of shRNA Against TRPV1 Attenuates Thermal Hyperalgesia in a Mouse Model of Peripheral Nerve Injury
Takashi Hirai,Mitsuhiro Enomoto,Hidetoshi Kaburagi,Shinichi Sotome,Kie Yoshida-Tanaka,Madoka Ukegawa,Hiroya Kuwahara,Mariko Yamamoto,Mio Tajiri,Haruka Miyata,Yukihiko Hirai,Makoto Tominaga,Kenichi Shinomiya,Hidehiro Mizusawa,Atsushi Okawa,Takanori Yokota +15 more
TL;DR: This study provides important evidence for the contribution of TRPV1 to thermal hypersensitivity in neuropathic pain and establishes intrathecal AAV9-mediated gene delivery as an investigative and potentially therapeutic platform for the nervous system.
Journal ArticleDOI
Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system.
Satoshi Zeniya,Hiroya Kuwahara,Kaiichi Daizo,Akihiro Watari,Masuo Kondoh,Kie Yoshida-Tanaka,Hidetoshi Kaburagi,Ken Asada,Tetsuya Nagata,Masahiro Nagahama,Kiyohito Yagi,Takanori Yokota +11 more
TL;DR: This proof‐of‐concept study demonstrated that intravenously injected angubindin‐1 increased the permeability of the blood–brain barrier and enabled transient delivery of subsequently administered antisense oligonucleotides into the mouse brain and spinal cord, leading to silencing of a target RNA without any overt adverse effects.