C
Christa de Ruiter
Researcher at Netherlands Organisation for Applied Scientific Research
Publications - 6
Citations - 1139
Christa de Ruiter is an academic researcher from Netherlands Organisation for Applied Scientific Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 3 publications receiving 1092 citations.
Papers
More filters
Journal ArticleDOI
Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD.
Eveline Gart,Everton Souto Lima,Frank H. J. Schuren,Christa de Ruiter,Joline Attema,Lars Verschuren,Jaap Keijer,Kanita Salic,Martine C. Morrison,Robert Kleemann +9 more
TL;DR: A first systematic analysis of microbiota changes in the ileum and colon using multiple diets and investigating both fecal and mucosal samples demonstrates correlations between the microbiota and dysfunctions of gut, adipose tissue, and liver, independent of a specific disease-inducing diet.
Journal ArticleDOI
A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology.
Anita M. van den Hoek,Lars Verschuren,Nicole Worms,Anita van Nieuwkoop,Christa de Ruiter,Joline Attema,Aswin L. Menke,Martien P. M. Caspers,Sridhar Radhakrishnan,Kanita Salic,Robert Kleemann,Robert Kleemann +11 more
TL;DR: A translational model of NASH with progressive liver fibrosis and simultaneous atherosclerosis development is defined by adaptation of the fat content of the diet, either insulin resistance (HFD) or hepatic inflammation and fibrosis (FFD) can be aggravated.
Journal ArticleDOI
A novel nutritional supplement prevents muscle loss and accelerates muscle mass recovery in caloric-restricted mice.
Anita M. van den Hoek,Gerben C.M. Zondag,Lars Verschuren,Christa de Ruiter,Joline Attema,Elly C. de Wit,Anne M.K. Schwerk,Bruno Guigas,Serene Lek,Annemarie Rietman,Rein Strijker,Robert Kleemann +11 more
TL;DR: Vital01 preserves muscle mass in a calorically restricted mouse model for muscle atrophy and restores body weight, fat and muscle mass more efficiently when compared to Fortisip Compact, and had preventive effects when administered during development of Muscle atrophy.
Journal ArticleDOI
The Human Milk Oligosaccharide 2′-Fucosyllactose Alleviates Liver Steatosis, ER Stress and Insulin Resistance by Reducing Hepatic Diacylglycerols and Improved Gut Permeability in Obese Ldlr-/-.Leiden Mice
Eveline Gart,Kanita Salic,Martine C. Morrison,Martin Giera,Joline Attema,Christa de Ruiter,Martien P. M. Caspers,Frank H. J. Schuren,Ivana Bobeldijk-Pastorova,Marianne Heer,Yan Qin,Robert Kleemann +11 more
TL;DR: Long-term supplementation with 2′-fucosyllactose can counteract the detrimental effects of HFD on gut dysbiosis and gut permeability and attenuates the development of liver steatosis, and provides a mechanistic rationale for the improvement of hyperinsulinemia.
Journal ArticleDOI
Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr−/−.Leiden mice
Eveline Gart,W. van Duyvenvoorde,Jessica Snabel,Christa de Ruiter,Joline Attema,Martien P. M. Caspers,Ser Miang. Lek,Bertie-Joan van Heuven,Arjen G. C. L. Speksnijder,Martin Giera,Aswin Menke,Kanita Salic,Kendra K. Bence,Gregory J. Tesz,Jaap Keijer,Robert Kleemann,Martine C. Morrison +16 more
TL;DR: In this paper , high-fat-diet (HFD)-fed Ldlr-/-.Leiden mice were compared to chow-fed controls, and liver, WAT depots and gut were analyzed biochemically, histologically and by lipidomics and transcriptomics together with circulating factors to investigate the sequence of pathogenic events and organ cross-talk during NAFLD development.