Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr−/−.Leiden mice
Eveline Gart,W. van Duyvenvoorde,Jessica Snabel,Christa de Ruiter,Joline Attema,Martien P. M. Caspers,Ser Miang. Lek,Bertie-Joan van Heuven,Arjen G. C. L. Speksnijder,Martin Giera,Aswin Menke,Kanita Salic,Kendra K. Bence,Gregory J. Tesz,Jaap Keijer,Robert Kleemann,Martine C. Morrison +16 more
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In this paper , high-fat-diet (HFD)-fed Ldlr-/-.Leiden mice were compared to chow-fed controls, and liver, WAT depots and gut were analyzed biochemically, histologically and by lipidomics and transcriptomics together with circulating factors to investigate the sequence of pathogenic events and organ cross-talk during NAFLD development.About:
This article is published in Heliyon.The article was published on 2023-02-01 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Medicine & Internal medicine.read more
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Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody
Florine Seidel,Kees Fluiter,Robert Kleemann,Nicole Worms,Anita van Nieuwkoop,Martien P. M. Caspers,Nikolaos Grigoriadis,Amanda J. Kiliaan,Frank Baas,Iliana Michailidou,Martine C. Morrison +10 more
TL;DR: In this paper , the effect of high-fat diet (HFD)-induced obesity on brain pathology in Ldlr-/-.Leiden mice was evaluated using histological and histochemical analysis.
References
More filters
Journal ArticleDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
NIH Image to ImageJ: 25 years of image analysis
TL;DR: The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.
Posted ContentDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
Causal analysis approaches in Ingenuity Pathway Analysis
TL;DR: This work presents a suite of algorithms and tools for inferring and scoring regulator networks upstream of gene-expression data based on a large-scale causal network derived from the Ingenuity Knowledge Base and extends the method to predict downstream effects on biological functions and diseases.
Journal ArticleDOI
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
Gijs den Besten,Karen van Eunen,Albert K. Groen,Koen Venema,Dirk-Jan Reijngoud,Barbara M. Bakker +5 more
TL;DR: This review summarizes the role of SCFAs in host energy metabolism, starting from the production by the gut microbiota to the uptake by the host and ending with the effects on host metabolism.