M
Martin Giera
Researcher at Leiden University Medical Center
Publications - 197
Citations - 5846
Martin Giera is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 35, co-authored 146 publications receiving 3628 citations. Previous affiliations of Martin Giera include Analysis Group & Ludwig Maximilian University of Munich.
Papers
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Journal ArticleDOI
Identification of bioactive metabolites using activity metabolomics
TL;DR: This Review focuses on recent progress in using metabolomics to understand how the metabolome influences other omics and, by extension, to reveal the active role of metabolites in physiology and disease.
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Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit
Zhuang Li,Chun-Xia Yi,Saeed Katiraei,Sander Kooijman,Enchen Zhou,Chih Kit Chung,Yuanqing Gao,José K. van den Heuvel,Onno C. Meijer,Jimmy F.P. Berbée,Marieke Heijink,Martin Giera,Ko Willems van Dijk,Albert K. Groen,Patrick C.N. Rensen,Yanan Wang +15 more
TL;DR: In this paper, the effect of butyrate on appetite and energy expenditure was investigated in mice following an intragastric gavage or intravenous injection of Butyrate, and an additional pair-fed group was included.
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Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
Elisa Giacomelli,Viviana Meraviglia,Giulia Campostrini,Amy Cochrane,Xu Cao,Ruben W.J. van Helden,Ana Krotenberg Garcia,Maria Mircea,Sarantos Kostidis,Richard P. Davis,Berend J. van Meer,Carolina R. Jost,Abraham J. Koster,Hailiang Mei,David G. Míguez,Aat A. Mulder,Mario Ledesma-Terrón,Giulio Pompilio,Luca Sala,Daniela C.F. Salvatori,Roderick C. Slieker,Roderick C. Slieker,Elena Sommariva,Antoine A.F. de Vries,Martin Giera,Stefan Semrau,Leon G.J. Tertoolen,Valeria V. Orlova,Milena Bellin,Milena Bellin,Christine L. Mummery,Christine L. Mummery +31 more
TL;DR: It is shown that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts, and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional microtissues (MTs).
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Protein digestion: an overview of the available techniques and recent developments.
TL;DR: An overview is given of the currently available digestion strategies and recent developments in the acceleration of the digestion process, and tailored approaches for classes of proteins that pose specific challenges are discussed.
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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
Rik van der Kant,Rik van der Kant,Vanessa F. Langness,Cheryl Herrera,Daniel A. Williams,Lauren K. Fong,Yves Leestemaker,Evelyne Steenvoorden,Kevin D. Rynearson,Jos F. Brouwers,J. Bernd Helms,Huib Ovaa,Martin Giera,Steven L. Wagner,Anne G. Bang,Lawrence S.B. Goldstein +15 more
TL;DR: A phenotypic screen for pTau accumulation in AD-patient iPSC-derived neurons is performed and cholesteryl esters (CE), the storage product of excess cholesterol, is identified as upstream regulators of Tau early during AD development.