Christa de Ruiter

TL;DR: A first systematic analysis of microbiota changes in the ileum and colon using multiple diets and investigating both fecal and mucosal samples demonstrates correlations between the microbiota and dysfunctions of gut, adipose tissue, and liver, independent of a specific disease-inducing diet.

TL;DR: A translational model of NASH with progressive liver fibrosis and simultaneous atherosclerosis development is defined by adaptation of the fat content of the diet, either insulin resistance (HFD) or hepatic inflammation and fibrosis (FFD) can be aggravated.

TL;DR: Vital01 preserves muscle mass in a calorically restricted mouse model for muscle atrophy and restores body weight, fat and muscle mass more efficiently when compared to Fortisip Compact, and had preventive effects when administered during development of Muscle atrophy.

TL;DR: Long-term supplementation with 2′-fucosyllactose can counteract the detrimental effects of HFD on gut dysbiosis and gut permeability and attenuates the development of liver steatosis, and provides a mechanistic rationale for the improvement of hyperinsulinemia.

TL;DR: In this paper , high-fat-diet (HFD)-fed Ldlr-/-.Leiden mice were compared to chow-fed controls, and liver, WAT depots and gut were analyzed biochemically, histologically and by lipidomics and transcriptomics together with circulating factors to investigate the sequence of pathogenic events and organ cross-talk during NAFLD development.