C
Christian G. Noble
Researcher at Novartis Institute for Tropical Diseases
Publications - 22
Citations - 2242
Christian G. Noble is an academic researcher from Novartis Institute for Tropical Diseases. The author has contributed to research in topics: Dengue virus & RNA polymerase. The author has an hindex of 17, co-authored 22 publications receiving 1855 citations. Previous affiliations of Christian G. Noble include Novartis.
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Ten years of dengue drug discovery: Progress and prospects
Siew Pheng Lim,Qing Yin Wang,Christian G. Noble,Yen Liang Chen,Hongping Dong,Bin Zou,Fumiaki Yokokawa,Shahul Nilar,Paul Smith,David Beer,Julien Lescar,Pei Yong Shi +11 more
TL;DR: The knowledge accumulated during the past decade has provided a better rationale for ongoing dengue drug discovery and it is optimistic that this continuous, concerted effort will lead to an effective d Dengue therapy.
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Strategies for development of Dengue virus inhibitors.
Christian G. Noble,Yen Liang Chen,Hongping Dong,Feng Gu,Siew Pheng Lim,Wouter Schul,Qing Yin Wang,Pei Yong Shi +7 more
TL;DR: The strategies discussed in this report should be applicable to antiviral development of other viruses, including dengue virus and other flaviviruses.
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Ligand-bound structures of the dengue virus protease reveal the active conformation.
TL;DR: Crystal structures of a peptide covalently bound to dengue virus serotype 3 (DENV-3) protease as well as the serine-protease inhibitor aprotinin bound to the same enzyme are reported, for the first time, to reveal a catalytically active, closed conformation of the DENV protease.
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The dengue virus NS5 protein as a target for drug discovery
TL;DR: This review summaries the current knowledge as well as prospective views on both MTase and RdRp activities of dengue virus NS5, which are well characterized, structurally and functionally, and inhibitors of both functions have been identified.
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The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease
Esther K. Schmitt,Meliana Riwanto,Vasan K. Sambandamurthy,Vasan K. Sambandamurthy,Silvio Roggo,Charlotte Miault,Christian Zwingelstein,Philipp Krastel,Christian G. Noble,David Beer,Srinivasa P. S. Rao,Melvin Au,Pornwaratt Niyomrattanakit,Vivian Lim,Jun Zheng,Douglas Jeffery,Kevin Pethe,Luis R. Camacho +17 more