S
Silvio Roggo
Researcher at Novartis
Publications - 40
Citations - 2087
Silvio Roggo is an academic researcher from Novartis. The author has contributed to research in topics: Cheminformatics & Drug discovery. The author has an hindex of 17, co-authored 40 publications receiving 1814 citations. Previous affiliations of Silvio Roggo include Max Planck Society & Scripps Research Institute.
Papers
More filters
Journal ArticleDOI
Oxysterols direct immune cell migration via EBI2
Sébastien Hannedouche,Juan Zhang,Tangsheng Yi,Weijun Shen,Weijun Shen,Deborah Nguyen,João Pereira,Danilo Guerini,Birgit Baumgarten,Silvio Roggo,Ben Wen,Richard Knochenmuss,Sophie Noël,François Gessier,Lisa M. Kelly,Miroslava Vanek,Stephane Laurent,Inga Preuss,Charlotte Miault,Isabelle Christen,Ratnaningrum Karuna,Wei Li,Dong-In Koo,Thomas Suply,Christian Schmedt,Eric C. Peters,Rocco Falchetto,Andreas Katopodis,Carsten Spanka,Marie-Odile Roy,Michel Detheux,Yu Chen,Peter G. Schultz,Charles Y. Cho,Klaus Seuwen,Jason G. Cyster,Andreas W. Sailer +36 more
TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.
Journal ArticleDOI
The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification.
TL;DR: A hierarchical classification of chemical scaffolds (molecular framework, which is obtained by pruning all terminal side chains) has been introduced and it is demonstrated that the classification procedure handles robustly synthetic structures and natural products.
Journal ArticleDOI
Natural product-likeness score and its application for prioritization of compound libraries.
TL;DR: A method is described to calculate the natural product-likeness score--a Bayesian measure which allows for the determination of how molecules are similar to the structural space covered by natural products and is shown to efficiently separate NPs from synthetic molecules in a cross-validation experiment.
Journal ArticleDOI
Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl.
Eddy A. Kragten,Isabelle Lalande,Kaspar Zimmermann,Silvio Roggo,Patrick Schindler,Dieter Müller,Jan van Oostrum,Peter C. Waldmeier,Peter Fürst +8 more
TL;DR: CGP 3466 is a structurally related analog ofR-(−)-deprenyl that exhibits virtually no monoamine oxidase type B inhibiting activity but is neuroprotective in the picomolar concentration range.
Journal ArticleDOI
The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease
Esther K. Schmitt,Meliana Riwanto,Vasan K. Sambandamurthy,Vasan K. Sambandamurthy,Silvio Roggo,Charlotte Miault,Christian Zwingelstein,Philipp Krastel,Christian G. Noble,David Beer,Srinivasa P. S. Rao,Melvin Au,Pornwaratt Niyomrattanakit,Vivian Lim,Jun Zheng,Douglas Jeffery,Kevin Pethe,Luis R. Camacho +17 more