Esther K. Schmitt

TL;DR: The preclinical profile for an optimized spiroindolone drug candidate, NITD609, shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model.

TL;DR: This work proposes the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.

TL;DR: The data suggest that stimulating IA production could promote anti-inflammatory responses and have therapeutic benefits, and the genetic capability of microbes to utilize mucins and metabolize tryptophan is diminished in IBD patients.

TL;DR: Improvement of the pharmacokinetic profile of the series translated to exceptional oral efficacy in the P. berghei infected malaria mouse model where full cure was achieved in four of five mice with three daily doses of 30 mg/kg.

TL;DR: Using postgenomic methods, including a yeast deletion strains collection, it is shown that cladosporin specifically inhibits protein synthesis by directly targeting P. falciparum cytosolic lysyl-tRNA synthetase.