Christian Koch

TL;DR: Although some of the treated patients eventually developed chronic PA infection, these patients had significantly better pulmonary function at the onset of chronicPA infection compared with control patients, and there was a trend suggesting that 3 months of high‐dose treatment with colistin inhalation and oral ciprofloxacin produced the best results in terms of postponement or prevention.

TL;DR: Presence of MBL variant alleles is associated with poor prognosis and early death in patients with CF and the predicted age of survival was reduced by 8 years in variant allele carriers when compared with normal homozygotes.

TL;DR: In this article, the authors derived the pre-exponential factor for the superparamagnetic relaxation time in the presence of an electric field gradient in accordance with the Blume-Tjon model from simultaneous fitting to ac and dc magnetization curves.

Abstract: Forty patients with cystic fibrosis and chronic broncho-pulmonary Pseudomonas aeruginosa infection entered a prospective double-blind placebo-controlled study of colistin inhalation. Active treatment consisted of inhalation of colistin one million units twice daily for three months and was compared to placebo inhalations of isotonic saline. Significantly more patients in the colistin inhalation group completed the study as compared to the placebo group (18 versus 11). Colistin treatment was superior to placebo treatment in terms of a significantly better clinical symptom score, maintenance of pulmonary function and inflammatory parameters. We recommend colistin inhalation therapy for cystic fibrosis patients with chronic P. aeruginosa lung infection as a supplementary treatment to frequent courses of intravenous anti-pseudomonas chemotherapy.

TL;DR: In this article, it was shown that green rust compounds can be used as a reductant for nitrate reduction to ammonium in abiotic systems in the presence of green rust.