C
Christian Twittenhoff
Researcher at Ruhr University Bochum
Publications - 10
Citations - 196
Christian Twittenhoff is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: RNA thermometer & Translation (biology). The author has an hindex of 5, co-authored 9 publications receiving 129 citations.
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Journal ArticleDOI
Temperature-responsive in vitro RNA structurome of Yersinia pseudotuberculosis
Francesco Righetti,Aaron M. Nuss,Christian Twittenhoff,Sascha Beele,Kristina Urban,Sebastian Will,Stephan H. Bernhart,Peter F. Stadler,Petra Dersch,Franz Narberhaus +9 more
TL;DR: A dynamic bacterial RNA structurome is presented and it is found that the expression of virulence-relevant functions in Y. pseudotuberculosis and reprogramming of its metabolism in response to temperature is associated with a restructuring of numerous mRNAs.
Journal ArticleDOI
RNA Thermometers in Bacterial Pathogens
Edmund Loh,Edmund Loh,Francesco Righetti,Hannes Eichner,Christian Twittenhoff,Franz Narberhaus +5 more
TL;DR: This review summarizes the present knowledge on virulence-related RNATs and discusses recent developments in the field to fine-tune virulence gene expression when the pathogen enters or exits the body of its host.
Journal ArticleDOI
Lead-seq: transcriptome-wide structure probing in vivo using lead(II) ions.
Christian Twittenhoff,Vivian B Brandenburg,Francesco Righetti,Aaron M. Nuss,Axel Mosig,Petra Dersch,Franz Narberhaus +6 more
TL;DR: The establishment of lead probing in a global RNA structuromics approach is reported, establishing Lead-seq as complementary approach to interrogate intracellular RNA structures on a global scale.
Journal ArticleDOI
An RNA thermometer dictates production of a secreted bacterial toxin.
TL;DR: A model, in which the RNA thermometer acts as translational roadblock in a two-layered regulatory cascade that tightly controls provision of the CNFY toxin during acute infection is concluded.
Journal ArticleDOI
A Salmonella Typhi RNA thermosensor regulates virulence factors and innate immune evasion in response to host temperature.
Susan M. Brewer,Christian Twittenhoff,Jens Kortmann,Sky W. Brubaker,Jared Honeycutt,Liliana M. Massis,Trung H.M. Pham,Franz Narberhaus,Denise M. Monack +8 more
TL;DR: In this paper, an RNA thermosensor (RNAT) was identified in the 5' untranslated region (UTR) of tviA encoded by the typhoid fever-causing bacterium Salmonella enterica serovar Typhi (S. Typhi).