Stephan H. Bernhart

TL;DR: In this article, exact dynamic programming algorithms can be used to compute ground states, base pairing probabilities, as well as thermodynamic properties of nucleic acids based on carefully measured thermodynamic parameters.

TL;DR: The Vienna RNA Websuite provides a web interface to the most commonly used programs of the Vienna RNA package and provides analysis of folding landscapes using the barriers program and structural RNA alignments using LocARNA.

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.

TL;DR: The accuracy of RNAalifold predictions can be improved substantially by introducing a different, more rational handling of alignment gaps, and by replacing the rather simplistic model of covariance scoring with more sophisticated RIBOSUM-like scoring matrices.