S
Sky W. Brubaker
Researcher at Stanford University
Publications - 18
Citations - 2667
Sky W. Brubaker is an academic researcher from Stanford University. The author has contributed to research in topics: Innate immune system & Inflammasome. The author has an hindex of 9, co-authored 16 publications receiving 2200 citations. Previous affiliations of Sky W. Brubaker include Boston Children's Hospital & University of California, Berkeley.
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Journal ArticleDOI
Innate immune pattern recognition: a cell biological perspective.
TL;DR: This review highlights aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
Journal ArticleDOI
The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides
John-Demian Sauer,Katia Sotelo-Troha,Jakob von Moltke,Kathryn M. Monroe,Chris S. Rae,Sky W. Brubaker,Mamoru Hyodo,Yoshihiro Hayakawa,Joshua J. Woodward,Daniel A. Portnoy,Russell E. Vance +10 more
TL;DR: A novel mutant mouse strain, Goldenticket (Gt), is described that fails to produce type I IFNs upon L. monocytogenes infection and provides new functions for Sting in the innate interferon response to pathogens.
Journal ArticleDOI
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
Karla L. Lightfield,Jenny L. Persson,Sky W. Brubaker,Chelsea E. Witte,Jakob von Moltke,Eric A. Dunipace,Thomas Henry,Yao Hui Sun,Dragana Cado,William F. Dietrich,Denise M. Monack,Renée M. Tsolis,Russell E. Vance +12 more
TL;DR: It is demonstrated that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems, clarifying the molecular basis for the cytosolic response to flageLLin.
Journal ArticleDOI
Differential Requirements for NAIP5 in Activation of the NLRC4 Inflammasome
Karla L. Lightfield,Jenny L. Persson,Jenny L. Persson,Norver J. Trinidad,Sky W. Brubaker,Sky W. Brubaker,Eric M. Kofoed,John-Demian Sauer,Eric A. Dunipace,Sarah E. Warren,Sarah E. Warren,Edward A. Miao,Russell E. Vance +12 more
TL;DR: It is demonstrated that the N terminus of flagellin can relieve the requirement for NAIP5 during the activation of the NLRC4 inflammasome, and the results indicate thatNAIP5 regulates the apparent specificity of theNLRC4Inflammasomes for distinct bacterial ligands.
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A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity
TL;DR: The existence of a functionally important bicistronic antiviral mRNA is revealed and a widespread role for polycistronic mRNAs in the innate immune system is suggested.