Showing papers by "Christian V. Stevens published in 2003"
TL;DR: The current review of 129 references describes the biological activity of several chitosan derivatives and the modes of action that have been postulated in the literature.
2,615 citations
TL;DR: The reaction of N-substituted 4-methyl-2-pyrrolidinones or 4-diethoxyphosphoryl analogues, carrying at least two chlorine atoms between the C(3) and C(6) carbons, with alkaline methoxide in methanol afforded the corresponding 5-methoxylated 3pyrrolin 2-ones, useful adducts for the preparation of agrochemicals or medicinal compounds as discussed by the authors.
25 citations
TL;DR: In this paper, 4-Aryl-4-phosphono-β-lactams are prepared by acylation of iminium salts with chloroacetyl chloride followed by phosphite addition and ring closure using sodium hydride as a base.
15 citations
TL;DR: In this article, a straightforward multigram synthesis of γ-amino-α,β-unsaturated phosphonates was described via a substitution-elimination sequence of dibromopropylphosphonates with primary amines.
Abstract: A straightforward multigram synthesis of γ-amino-α,β-unsaturated phosphonates is described via a substitution-elimination sequence of dibromopropylphosphonates with primary amines. Depending on the primary amine, a one or two step procedure was utilized.
8 citations
Journal Article•
7 citations
TL;DR: In this paper, the synthesis of tricyclic amino ester 12 is described, which contains the 2-azatricyclo[3.3.0.03,6] octane skeleton.
Abstract: The synthesis of the tricyclic amino ester 12 is described. This constrained proline analogue contains the formerly unknown 2-azatricyclo[3.3.0.03,6]octane skeleton. A short 5 step sequence was developed allowing the production of 12 on a multi-gram scale. The key step consists of a stereoselective synthesis of a hydantoin that, after conversion to the amino ester, can be brominated and ring closed to the 2-azatricyclo[3.3.0.03,6]octane skeleton.
4 citations