C
Christiane Deval
Researcher at University of Auvergne
Publications - 37
Citations - 1708
Christiane Deval is an academic researcher from University of Auvergne. The author has contributed to research in topics: Cathepsin B & Cathepsin. The author has an hindex of 18, co-authored 36 publications receiving 1566 citations. Previous affiliations of Christiane Deval include French Institute of Health and Medical Research & Institut national de la recherche agronomique.
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Journal ArticleDOI
Leucine Limitation Induces Autophagy and Activation of Lysosome-dependent Proteolysis in C2C12 Myotubes through a Mammalian Target of Rapamycin-independent Signaling Pathway
TL;DR: Results suggest that autophagy is an essential cellular response for increasing protein breakdown in muscle following food deprivation, and clear evidence is provided that the mTOR signaling pathway is not involved in the mediation of leucine effects on both protein synthesis and degradation in C2C12 myotubes.
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Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting.
Christiane Deval,Sylvie Mordier,Christiane Obled,Daniel Béchet,Lydie Combaret,Didier Attaix,Marc Ferrara +6 more
TL;DR: A positive and direct correlation between cathepsin L mRNA and protein level and the intensity of proteolysis is demonstrated, and cathePSin L is identified as an appropriate early marker of muscle wasting.
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TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.
Céline Jousse,Christiane Deval,Anne-Catherine Maurin,Laurent Parry,Yoan Cherasse,Cédric Chaveroux,Renaud Lefloch,Philippe Lenormand,Alain Bruhat,Pierre Fafournoux +9 more
TL;DR: This study describes how induction of the human homolog of Drosophila tribbles (TRB3) attenuates the integrated stress response (ISR) by a negative feedback mechanism and identifies TRB3 as anegative feedback regulator of the ATF4-dependent transcription and participates to the fine regulation of the ISR.
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Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: a new mechanism of the action of polyphenols.
Dragan Milenkovic,Christiane Deval,Erwan Gouranton,Erwan Gouranton,Jean-François Landrier,Jean-François Landrier,Augustin Scalbert,Christine Morand,Andrzej Mazur +8 more
TL;DR: This in vivo study demonstrated for the first time that polyphenols at nutritional doses modulate the expression of miRNA in the liver.
Journal ArticleDOI
Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways.
Christiane Deval,Cédric Chaveroux,Anne-Catherine Maurin,Yoan Cherasse,Laurent Parry,Valérie Carraro,Dragan Milenkovic,Marc Ferrara,Alain Bruhat,Céline Jousse,Pierre Fafournoux +10 more
TL;DR: It is found that a 6 h period of leucine starvation regulated the expression of a specific set of genes: 420 genes were up‐regulated by more than 1.8‐fold and 311 genes were down‐regulated, and the GCN2 pathway was the major, but not unique, signaling pathway involved in the up and down‐regulation of gene expression in response to amino acid starvation.