V
Valérie Carraro
Researcher at Institut national de la recherche agronomique
Publications - 35
Citations - 2526
Valérie Carraro is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Amino acid & Regulation of gene expression. The author has an hindex of 20, co-authored 33 publications receiving 2207 citations.
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Journal ArticleDOI
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
Wafa B'chir,Anne-Catherine Maurin,Valérie Carraro,Julien Averous,Céline Jousse,Yuki Muranishi,Laurent Parry,Georges Stepien,Pierre Fafournoux,Alain Bruhat +9 more
TL;DR: A novel regulatory role of the eIF2α–ATF4 pathway is revealed in the fine-tuning of the autophagy gene transcription program in response to stresses.
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Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.
TL;DR: In this article, a genomic cis-acting element (amino acid response element (AARE) was found to be involved in the transcriptional activation of the human CHOP gene by leucine starvation and shown that it binds the activating transcription factor 2 (ATF2).
Journal ArticleDOI
Amino Acids Control Mammalian Gene Transcription: Activating Transcription Factor 2 Is Essential for the Amino Acid Responsiveness of the CHOP Promoter
Alain Bruhat,Céline Jousse,Valérie Carraro,Andreas M. Reimold,Marc Ferrara,Pierre Fafournoux +5 more
TL;DR: The results suggest that ATF-2 may be a member of a cascade of molecular events by which the cellular concentration of amino acids can regulate mammalian gene expression.
Journal ArticleDOI
Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5′UTR
Céline Jousse,Alain Bruhat,Valérie Carraro,Fumihiko Urano,Marc Ferrara,David Ron,Pierre Fafournoux +6 more
TL;DR: It is shown here that the 5'UTR of the Chop transcript plays an important role in controlling the synthesis of CHOP protein, which contains a conserved uORF which encodes a 31 amino acid peptide that inhibits the expression of the downstream ORF.
Journal ArticleDOI
Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome
Céline Jousse,Céline Jousse,Laurent Parry,Sarah Lambert-Langlais,Anne-Catherine Maurin,Julien Averous,Alain Bruhat,Valérie Carraro,Jörg Tost,Philippe Lettéron,Patty Chen,Ralf Jockers,Jean-Marie Launay,Jacques Mallet,Pierre Fafournoux,Pierre Fafournoux +15 more
TL;DR: This study investigates the consequences of maternal undernutrition during gestation and lactation on DNA methylation and expression of the leptin gene, which plays a major regulatory role in coordinating nutritional state with many aspects of mammalian biology, and shows that animals born to mothers fed a low‐protein‐diet (F1‐LPD group) have a lower body weight/adiposity and exhibit a higher food intake.