L
Laurent Parry
Researcher at Institut national de la recherche agronomique
Publications - 36
Citations - 2211
Laurent Parry is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: ATF4 & Amino acid. The author has an hindex of 18, co-authored 34 publications receiving 1892 citations.
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Journal ArticleDOI
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
Wafa B'chir,Anne-Catherine Maurin,Valérie Carraro,Julien Averous,Céline Jousse,Yuki Muranishi,Laurent Parry,Georges Stepien,Pierre Fafournoux,Alain Bruhat +9 more
TL;DR: A novel regulatory role of the eIF2α–ATF4 pathway is revealed in the fine-tuning of the autophagy gene transcription program in response to stresses.
Journal ArticleDOI
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
Anne-Catherine Maurin,Céline Jousse,Julien Averous,Laurent Parry,Alain Bruhat,Yoan Cherasse,Huiqing Zeng,Yuhong Zhang,Heather P. Harding,David Ron,Pierre Fafournoux +10 more
TL;DR: It is reported that brain-specific inactivation of GCN2, a ubiquitously expressed protein kinase that phosphorylates translation initiation factor 2 alpha (eIF2alpha) in response to intracellular amino acid deficiency, impairs this aversive response.
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TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.
Céline Jousse,Christiane Deval,Anne-Catherine Maurin,Laurent Parry,Yoan Cherasse,Cédric Chaveroux,Renaud Lefloch,Philippe Lenormand,Alain Bruhat,Pierre Fafournoux +9 more
TL;DR: This study describes how induction of the human homolog of Drosophila tribbles (TRB3) attenuates the integrated stress response (ISR) by a negative feedback mechanism and identifies TRB3 as anegative feedback regulator of the ATF4-dependent transcription and participates to the fine regulation of the ISR.
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Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome
Céline Jousse,Céline Jousse,Laurent Parry,Sarah Lambert-Langlais,Anne-Catherine Maurin,Julien Averous,Alain Bruhat,Valérie Carraro,Jörg Tost,Philippe Lettéron,Patty Chen,Ralf Jockers,Jean-Marie Launay,Jacques Mallet,Pierre Fafournoux,Pierre Fafournoux +15 more
TL;DR: This study investigates the consequences of maternal undernutrition during gestation and lactation on DNA methylation and expression of the leptin gene, which plays a major regulatory role in coordinating nutritional state with many aspects of mammalian biology, and shows that animals born to mothers fed a low‐protein‐diet (F1‐LPD group) have a lower body weight/adiposity and exhibit a higher food intake.
Journal ArticleDOI
Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways.
Christiane Deval,Cédric Chaveroux,Anne-Catherine Maurin,Yoan Cherasse,Laurent Parry,Valérie Carraro,Dragan Milenkovic,Marc Ferrara,Alain Bruhat,Céline Jousse,Pierre Fafournoux +10 more
TL;DR: It is found that a 6 h period of leucine starvation regulated the expression of a specific set of genes: 420 genes were up‐regulated by more than 1.8‐fold and 311 genes were down‐regulated, and the GCN2 pathway was the major, but not unique, signaling pathway involved in the up and down‐regulation of gene expression in response to amino acid starvation.