C
Christina Rau
Researcher at GlaxoSmithKline
Publications - 19
Citations - 6121
Christina Rau is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Chemoproteomics & Proteomics. The author has an hindex of 12, co-authored 19 publications receiving 5657 citations.
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Journal ArticleDOI
Proteome survey reveals modularity of the yeast cell machinery
Anne-Claude Gavin,Patrick Aloy,Paola Grandi,Roland Krause,Markus Boesche,Martina Marzioch,Christina Rau,Lars Juhl Jensen,Sonja Bastuck,Birgit Dümpelfeld,Angela Edelmann,Marie-Anne Heurtier,Verena Hoffman,Christian Hoefert,Karin Klein,Manuela Hudak,Anne-Marie Michon,Malgorzata Schelder,Markus Schirle,Marita Remor,Tatjana Rudi,Sean D. Hooper,Andreas Bauer,Tewis Bouwmeester,Georg Casari,Gerard Drewes,Gitte Neubauer,Jens Rick,Bernhard Kuster,Peer Bork,Robert B. Russell,Giulio Superti-Furga +31 more
TL;DR: This study reports the first genome-wide screen for complexes in an organism, budding yeast, using affinity purification and mass spectrometry and provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling.
Journal ArticleDOI
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih Min A Huang,Yuji Mishina,Shanming Liu,Atwood K. Cheung,Frank Stegmeier,Gregory A. Michaud,Olga Charlat,Elizabeth Wiellette,Yue Zhang,Stephanie Wiessner,Marc Hild,Xiaoying Shi,Christine D. Wilson,Craig Mickanin,Vic E. Myer,Aleem Fazal,Ronald Tomlinson,Fabrizio C. Serluca,Wenlin Shao,Hong Cheng,Michael Shultz,Christina Rau,Markus Schirle,Judith Schlegl,Sonja Ghidelli,Stephen Fawell,Chris Lu,Daniel Curtis,Marc W. Kirschner,Christoph Lengauer,Peter Finan,John A. Tallarico,Tewis Bouwmeester,Jeffery A. Porter,Andreas Bauer,Feng Cong +35 more
TL;DR: This study uses a chemical genetic screen to identify a small molecule, XAV939, which selectively inhibits β-catenin-mediated transcription and reveals new mechanistic insights into the regulation of axin protein homeostasis, which presents new avenues for targeted Wnt pathway therapies.
Journal ArticleDOI
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Marcus Bantscheff,Dirk Eberhard,Yann Abraham,Sonja Bastuck,Markus Boesche,Scott Hobson,Toby Mathieson,Jessica Perrin,Manfred Raida,Christina Rau,Valerie Reader,Gavain Sweetman,Andreas Bauer,Tewis Bouwmeester,Carsten Hopf,Ulrich Kruse,Gitte Neubauer,Nigel Ramsden,Jens Rick,Bernhard Kuster,Gerard Drewes +20 more
TL;DR: Quantitative profiling of the drugs Imatinib, dasatinib and bosutinib in K562 cells confirms known targets including ABL and SRC family kinases and identifies the receptor tyrosine kinase DDR1 and the oxidoreductase NQO2 as novel targets of imatinib.
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A selective inhibitor reveals PI3Kγ dependence of T H 17 cell differentiation
Giovanna Bergamini,Kathryn Bell,Satoko Shimamura,Thilo Werner,Andrew Cansfield,Katrin Müller,Jessica Perrin,Christina Rau,Katie Ellard,Carsten Hopf,Carola Doce,Daniel Leggate,Raffaella Mangano,Toby Mathieson,Alison O'Mahony,Ivan Plavec,Faiza Rharbaoui,Friedrich B M Reinhard,Mikhail M. Savitski,Nigel Ramsden,Emilio Hirsch,Gerard Drewes,Oliver Rausch,Marcus Bantscheff,Gitte Neubauer +24 more
TL;DR: High-throughput chemoproteomics method enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts resulted in CZC24832, which is to the authors' knowledge the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation.
Journal ArticleDOI
Multiple cyclophilins involved in different cellular pathways mediate HCV replication
L. Alex Gaither,Jason Borawski,Leah J. Anderson,Kara Balabanis,Piroska Dévay,Gerard Joberty,Christina Rau,Markus Schirle,Tewis Bouwmeester,Craig Mickanin,Shan Chuan Zhao,Chad Vickers,Lac Lee,Gejing Deng,Jeremy Baryza,Roger Aki Fujimoto,Kai Lin,Teresa Compton,Brigitte Wiedmann +18 more
TL;DR: Together, the experiments provide strong evidence that NIM811 reduces viral replication by inhibition of multiple cyclophilins and pathways with protein trafficking as the most strongly and persistently affected pathway.