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Yann Abraham
Researcher at Janssen Pharmaceutica
Publications - 18
Citations - 2384
Yann Abraham is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Population & Hippo signaling pathway. The author has an hindex of 10, co-authored 17 publications receiving 2107 citations. Previous affiliations of Yann Abraham include Curie Institute & Novartis.
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Journal ArticleDOI
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Marcus Bantscheff,Dirk Eberhard,Yann Abraham,Sonja Bastuck,Markus Boesche,Scott Hobson,Toby Mathieson,Jessica Perrin,Manfred Raida,Christina Rau,Valerie Reader,Gavain Sweetman,Andreas Bauer,Tewis Bouwmeester,Carsten Hopf,Ulrich Kruse,Gitte Neubauer,Nigel Ramsden,Jens Rick,Bernhard Kuster,Gerard Drewes +20 more
TL;DR: Quantitative profiling of the drugs Imatinib, dasatinib and bosutinib in K562 cells confirms known targets including ABL and SRC family kinases and identifies the receptor tyrosine kinase DDR1 and the oxidoreductase NQO2 as novel targets of imatinib.
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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
Marcus Bantscheff,Carsten Hopf,Mikhail M. Savitski,Antje Dittmann,Paola Grandi,Anne-Marie Michon,Judith Schlegl,Yann Abraham,Isabelle Becher,Giovanna Bergamini,Markus Boesche,Manja Delling,Birgit Dümpelfeld,Dirk Eberhard,Carola Huthmacher,Toby Mathieson,Daniel Poeckel,Valerie Reader,Katja Strunk,Gavain Sweetman,Ulrich Kruse,Gitte Neubauer,Nigel Ramsden,Gerard Drewes +23 more
TL;DR: This work revealed the selectivity with which 16 HDAC inhibitors target multiple HDAC complexes scaffolded by ELM-SANT domain subunits, including a novel mitotic deacetylase complex (MiDAC) and identified several non-HDAC targets for hydroxamate inhibitors.
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YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors
Patricia Marti,Claudia Stein,Tanja Blumer,Yann Abraham,Michael T. Dill,Monika Pikiolek,Vanessa Orsini,Giorgia Jurisic,Philippe Megel,Zuzanna Makowska,Claudia Agarinis,Luigi Tornillo,Tewis Bouwmeester,Heinz Ruffner,Andreas Bauer,Christian N. Parker,Tobias Schmelzle,Luigi Terracciano,Markus H. Heim,Jan S. Tchorz +19 more
TL;DR: These findings establish YAP as a key regulator of proliferation and antiapoptotic mechanisms in CC and provide first evidence that YAP promotes angiogenesis by regulating the expression of secreted proangiogenic proteins.
Journal ArticleDOI
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.
Dominic Hoepfner,Stephen B. Helliwell,Heather Sadlish,Sven Schuierer,Ireos Filipuzzi,Sophie Brachat,Bhupinder Bhullar,Uwe Plikat,Yann Abraham,Marc Altorfer,Thomas Aust,Lukas Baeriswyl,Raffaele Cerino,Lena Chang,David Estoppey,Juerg Eichenberger,Mathias Frederiksen,Nicole Hartmann,Annika Hohendahl,Britta Knapp,Philipp Krastel,Nicolas Melin,Florian Nigsch,Edward J. Oakeley,Virginie Petitjean,Frank Petersen,Ralph Riedl,Esther K. Schmitt,Frank Staedtler,Christian Studer,John A. Tallarico,Stefan Wetzel,Mark C. Fishman,Jeffrey A. Porter,N. Rao Movva +34 more
TL;DR: Using an optimized platform, the relative sensitivities of the heterozygous and homozygous deletion collections for nearly 1800 biologically active compounds are provided, providing unique insights into pathways that are sensitive and resistant to a given perturbation.
Journal ArticleDOI
A Role for Centrin 3 in Centrosome Reproduction
Sandrine Middendorp,Thomas Küntziger,Yann Abraham,Simon Holmes,Nicole Bordes,Michel Paintrand,Anne Paoletti,Michel Bornens +7 more
TL;DR: The results demonstrate that, in spite of the large differences in centrosome structure among widely divergent species, the Centrosome pathway of reproduction is conserved.