C
Christina V. Angeles
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 4
Citations - 237
Christina V. Angeles is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Liposarcoma & Cellular differentiation. The author has an hindex of 3, co-authored 4 publications receiving 208 citations.
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Journal ArticleDOI
Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas
Barry S. Taylor,Penelope DeCarolis,Christina V. Angeles,Fabienne Brenet,Nikolaus Schultz,Cristina R. Antonescu,Joseph M. Scandura,Chris Sander,Agnes Viale,Nicholas D. Socci,Samuel Singer +10 more
TL;DR: Multimodality sequence analysis of DLPS revealed recurrent mutations and epigenetic abnormalities critical to liposarcomagenesis and to the suppression of adipocyte differentiation, revealing an unanticipated role for methylation abnormalities in DLPS tumors and suggesting demethylating agents as potential therapeutics.
Journal ArticleDOI
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.
Ryan M. Gobble,Li-Xuan Qin,Elliott R. Brill,Christina V. Angeles,Stacy Ugras,Rachael O'Connor,Nicole Moraco,Penelope DeCarolis,Cristina R. Antonescu,Samuel Singer +9 more
TL;DR: Findings identify genes that seem to be involved in liposarcomagenesis and have promise as therapeutic targets, and support the use of this multigene predictor for distant recurrence-free survival to improve risk stratification for individual patients with lipOSarcoma.
Journal ArticleDOI
ZIC1 Overexpression Is Oncogenic in Liposarcoma
Elliott R. Brill,Ryan M. Gobble,Christina V. Angeles,Mariana Lagos-Quintana,Aimee M. Crago,Bernadette Laxa,Penelope DeCarolis,Lei Zhang,Cristina R. Antonescu,Nicholas D. Socci,Barry S. Taylor,Chris Sander,Andrew Koff,Samuel Singer +13 more
TL;DR: The results show that Z IC1 expression is essential for liposarcomagenesis and that targeting ZIC1 or its downstream targets might lead to novel therapy for lipOSarcoma.