Penelope DeCarolis

TL;DR: An integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes of soft-tissue sarcomas yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy.

TL;DR: It is shown that Nutlin-3a, an antagonist of MDM2, preferentially induces apoptosis and growth arrest in dedifferentiated liposarcoma cells compared with normal adipocytes, and the promise of using this expression dataset for new drug discovery in liposARcoma is shown.

TL;DR: A comprehensive computational approach to robustly map chromosomal alterations in tumor samples and assess their functional importance in cancer is presented, applicable to high-resolution genomic data.

TL;DR: Re-expression vectors or selective agents directed at miR-143 or its targets may have therapeutic value in dedifferentiated liposarcoma, and treatment with a PLK1 inhibitor potently induced G(2)-M growth arrest and apoptosis in liposARcoma cells.

TL;DR: Multimodality sequence analysis of DLPS revealed recurrent mutations and epigenetic abnormalities critical to liposarcomagenesis and to the suppression of adipocyte differentiation, revealing an unanticipated role for methylation abnormalities in DLPS tumors and suggesting demethylating agents as potential therapeutics.