R
Raya Khanin
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 64
Citations - 12071
Raya Khanin is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Regulation of gene expression & Gene. The author has an hindex of 31, co-authored 59 publications receiving 10773 citations. Previous affiliations of Raya Khanin include University of Glasgow & Kettering University.
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Journal ArticleDOI
Widespread changes in protein synthesis induced by microRNAs
Matthias Selbach,Björn Schwanhäusser,Nadine Thierfelder,Zhuo Fang,Raya Khanin,Nikolaus Rajewsky +5 more
TL;DR: It is shown that a single miRNA can repress the production of hundreds of proteins, but that this repression is typically relatively mild, and the data suggest that a mi RNA can, by direct or indirect effects, tune protein synthesis from thousands of genes.
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IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu,Patrick S. Ward,Patrick S. Ward,Gurpreet S. Kapoor,Dan Rohle,Dan Rohle,Sevin Turcan,Omar Abdel-Wahab,Christopher R. Edwards,Raya Khanin,Maria E. Figueroa,Ari Melnick,Kathryn E. Wellen,Donald M. O'Rourke,Shelley L. Berger,Timothy A. Chan,Ross L. Levine,Ingo K. Mellinghoff,Ingo K. Mellinghoff,Craig B. Thompson +19 more
TL;DR: It is reported that 2HG-producing IDH mutants can prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells, and that inhibition of histone methylation can be sufficient to block the differentiation of non-transformed cells.
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Mutations in GNA11 in Uveal Melanoma
Catherine D. Van Raamsdonk,Klaus G. Griewank,Michelle B. Crosby,Maria C. Garrido,Swapna S. Vemula,Thomas Wiesner,Anna C. Obenauf,Werner Wackernagel,Gary G. R. Green,Nancy Bouvier,M. Mert Sozen,Gail Baimukanova,Ritu Roy,Adriana Heguy,Igor Dolgalev,Raya Khanin,Klaus J. Busam,Michael R. Speicher,Joan M. O'Brien,Boris C. Bastian +19 more
TL;DR: Constitutive activation of the pathway involving these two genes appears to be a major contributor to the development of uveal melanoma.
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Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.
Krista Dubin,Margaret K. Callahan,Boyu Ren,Raya Khanin,Agnes Viale,Lilan Ling,Daniel No,Asia Gobourne,Eric R. Littmann,Curtis Huttenhower,Curtis Huttenhower,Eric G. Pamer,Eric G. Pamer,Jedd D. Wolchok +13 more
TL;DR: It is demonstrated that increased representation of bacteria belonging to the Bacteroidetes phylum is correlated with resistance to the development of checkpoint-blockade-induced colitis, and a paucity of genetic pathways involved in polyamine transport and B vitamin biosynthesis is associated with an increased risk of colitis.
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Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data
Franck Rapaport,Raya Khanin,Yupu Liang,Mono Pirun,Azra Krek,Paul Zumbo,Christopher E. Mason,Nicholas D. Socci,Doron Betel +8 more
TL;DR: A large number of computational methods have been developed for analyzing differential gene expression in RNA-seq data as discussed by the authors, and a comprehensive evaluation of common methods using the SEQC benchmark dataset and ENCODE data.