J
Joseph M. Scandura
Researcher at Cornell University
Publications - 93
Citations - 3698
Joseph M. Scandura is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Progenitor cell. The author has an hindex of 27, co-authored 78 publications receiving 3101 citations. Previous affiliations of Joseph M. Scandura include Temple University & Kettering University.
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Journal ArticleDOI
DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing
Fabienne Brenet,Michelle Moh,Patricia Funk,Erika Feierstein,Agnes Viale,Nicholas D. Socci,Joseph M. Scandura +6 more
TL;DR: Dense methylation surrounding the transcription start site (TSS) is uncoupled from methylation within more downstream regions suggesting that there are at least two classes of intragenic methylation, and direct evidence that DNA methylation is interpreted dissimilarly in different regions of the gene body is provided.
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Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation
TL;DR: A molecular pathway by which TGFbeta mediates its cytostatic effects on human hematopoietic cells is identified and an explanation for the frequent silencing of p57 expression is suggested.
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Reprogramming human endothelial cells to haematopoietic cells requires vascular induction
Vladislav M. Sandler,Raphael Lis,Ying Liu,A. Kedem,Daylon James,Olivier Elemento,Jason M. Butler,Joseph M. Scandura,Shahin Rafii +8 more
TL;DR: This work has devised a method to phenocopy the vascular-niche microenvironment of haemogenic cells, thereby enabling reprogramming of human endothelial cells into engraftable haematopoietic cells without transition through a pluripotent intermediate.
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Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Sakari Vanharanta,Weiping Shu,Fabienne Brenet,A. Ari Hakimi,Adriana Heguy,Agnes Viale,Victor E. Reuter,James J. Hsieh,Joseph M. Scandura,Joan Massagué,Joan Massagué +10 more
TL;DR: It is shown that during ccRCC progression, cancer cells exploit diverse epigenetic alterations to empower a branch of the VHL-HIF pathway for metastasis, and the strength of this activation is associated with poor clinical outcome.
Journal ArticleDOI
Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance
Zhongwei Cao,Bi-Sen Ding,Peipei Guo,Sharrell Lee,Jason M. Butler,Stephanie C. Casey,Michael Simons,Wayne Tam,Dean W. Felsher,Koji Shido,Arash Rafii,Joseph M. Scandura,Shahin Rafii +12 more
TL;DR: It is shown that FGF4 produced by B cell lymphoma cells (LCs) through activating FGFR1 upregulates the Notch ligand Jagged1 (Jag1) on neighboring ECs.