C
Christine Ambrose
Researcher at Biogen Idec
Publications - 86
Citations - 27342
Christine Ambrose is an academic researcher from Biogen Idec. The author has contributed to research in topics: B-cell activating factor & B cell. The author has an hindex of 42, co-authored 83 publications receiving 26300 citations. Previous affiliations of Christine Ambrose include Harvard University.
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Journal ArticleDOI
Anti-CD19 CAR T cells potently redirected to kill solid tumor cells.
Christine Ambrose,Lihe Su,Lan Wu,Fay J. Dufort,Thomas J Sanford,Alyssa Birt,Benjamin J. Hackel,Andreas Hombach,Hinrich Abken,Roy R. Lobb,Paul Rennert +10 more
TL;DR: In this article, a CAR-CD19 T cell that secretes a CD19-anti-Her2 bridging protein was developed, which can be exploited to attack tumor antigens on any cancer.
Journal ArticleDOI
A Novel CD19-Anti-CD20 Bridging Protein Prevents and Reverses CD19-Negative Relapse from CAR19 T Cell Treatment In Vivo
Paul Rennert,Lihe Su,Fay J. Dufort,Alyssa Birt,Thomas J Sanford,Lan Wu,Christine Ambrose,Roy R. Lobb +7 more
TL;DR: This technology is presented and illustrated its' ability to prevent relapses and importantly, to reverse relapses in vivo and to provide a highly attractive alternative to subsequent CAR T therapy.
Journal ArticleDOI
Anti-CD19 CAR T cells that secrete a biparatopic anti-CLEC12A bridging protein have potent activity against aggressive acute myeloid leukemia in vitro and in vivo
Paul Rennert,Fay J. Dufort,Lihe Su,Thomas J Sanford,Alyssa Birt,Lan Wu,Roy R. Lobb,Christine Ambrose +7 more
TL;DR: In this paper, a biparatopic bridging protein was designed for CAR-T cell engagers, with a CAR-targeted protein fused to antigen binding domains derived from antibodies.
Journal ArticleDOI
Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3.
Ingrid Pribill,Glenn Barnes,Jianmin Chen,Deanna Church,Alan Buckler,Sarah Baxendale,Gillian P. Bates,Hans Lehrach,Matthew J. Gusella,Mabel P. Duyao,Christine Ambrose,James F. Gusella,Marcy E. MacDonald +12 more
TL;DR: Exon amplification, GRAIL2 exon prediction and EST database searching produced a transcription map of 30 loci in this segment of 4p16.3 that includes known human genes, homologs of loci identified in rodents and several anonymous transcripts.
Posted ContentDOI
CD19-targeting CAR T cells potently redirected to kill solid tumor cells
Christine Ambrose,Lihe Su,Lan Wu,Fay J. Dufort,Thomas J Sanford,Alyssa Birt,Benjamin J. Hackel,Andreas Hombach,Hinrich Abken,Roy R. Lobb,Paul D. Rennert +10 more
TL;DR: A CAR-CD19 T cell that secretes a CD19-anti-Her2 bridging protein that can be exploited to attack tumor antigens on any cancer, and incorporates critical attributes for successful solid tumor cell therapy.