C
Christine Ambrose
Researcher at Biogen Idec
Publications - 86
Citations - 27342
Christine Ambrose is an academic researcher from Biogen Idec. The author has contributed to research in topics: B-cell activating factor & B cell. The author has an hindex of 42, co-authored 83 publications receiving 26300 citations. Previous affiliations of Christine Ambrose include Harvard University.
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Journal ArticleDOI
Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals
G B Landwehrmeyer,Sandra M. McNeil,L S Dure th,P. Ge,H. Aizawa,Qin Huang,Christine Ambrose,Mabel P. Duyao,Edward D. Bird,Ernesto Bonilla +9 more
TL;DR: The lack of correlation between the levels of IT15 mRNA expression and susceptibility to degeneration in HD strongly suggests that the mutant gene acts in concert with other factors to cause the distinctive pattern of neurodegeneration inHD.
Journal ArticleDOI
Gametic but not somatic instability of CAG repeat length in Huntington's disease.
Marcy E. MacDonald,Gary T. Barnes,Jayalakshmi Srinidhi,Mabel P. Duyao,Christine Ambrose,Richard H. Myers,Jonathon Gray,P. M. Conneally,Ah Young,J. B. Penney +9 more
TL;DR: The data indicate that the developmental timing of repeat instability appears to differ between HD and fragile X syndrome, and that the fundamental mechanisms leading to repeat expansion may therefore be distinct.
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Characterization of the G Protein-coupled Receptor Kinase GRK4 IDENTIFICATION OF FOUR SPLICE VARIANTS
Richard T. Premont,Alexander D. Macrae,Robert H. Stoffel,Namjin Chung,Julie A. Pitcher,Christine Ambrose,James Inglese,Marcy E. MacDonald,Robert J. Lefkowitz +8 more
TL;DR: A novel human G protein-coupled receptor kinase was recently identified by positional cloning in the search for the Huntington's disease locus (Ambrose et al. as mentioned in this paper ).
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BAFF production by antigen-presenting cells provides T cell co-stimulation.
Bertrand Huard,Lionel Arlettaz,Christine Ambrose,Vincent Kindler,Davide Mauri,Eddy Roosnek,Jürg Tschopp,Pascal Schneider,Lars E. French +8 more
TL;DR: Estimation of expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co-stimulatory function indicates that BAFF may regulate T cell immunity during APC-T cell interactions and as an autocrine factor once T cells have detached from the APC.
Journal Article
Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes.
J L Browning,Irene Sizing,Pornsri Lawton,P R Bourdon,Paul D. Rennert,Gerard R. Majeau,Christine Ambrose,Catherine Hession,Konrad Miatkowski,D A Griffiths,Apinya Ngam-ek,Werner Meier,Christopher D. Benjamin,P S Hochman +13 more
TL;DR: It is shown that on mononuclear cells, surface LT complexes and receptor are expressed similarly in mice and man, and the tools described herein form the foundation for study of the functional roles of the LT system in the mouse.