Christine Ambrose

TL;DR: The study revealed that ligand-receptor pairs are either cross-reactive between human and mouse, strictly species- specific (GITR/GITRL), or partially species-specific (e.g. Tweak/Fn14, RANK/RANKL).

TL;DR: Evidence is presented that a TNF family member called TWEAK (TNF-like weak inducer of apoptosis) stimulates oval cell proliferation in mouse liver through its receptor Fn14, and it is concluded that T WEAK has a selective mitogenic effect for liver oval cells that distinguishes it from other previously described growth factors.

TL;DR: Observations suggest that the dominant HD mutation either confers a new property on the mRNA or alters an interaction at the protein level, suggesting the operation of interacting factors in determining specificity of cell loss.

TL;DR: An important role is suggested for APRIL in tumorigenesis and a novel anticancer strategy is pointed towards by identifying B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), two predicted members of the TNF receptor family.

TL;DR: Nine families with potential de novo expression of Huntington's disease are examined, finding elderly unaffected relatives inherited the same chromosome as that containing the expanded repeat in the proband, but had repeat lengths of 34–38 units, spanning the gap between the normal and HD distributions.