C
Christine Mézard
Researcher at Université Paris-Saclay
Publications - 9
Citations - 642
Christine Mézard is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Homologous recombination & Meiosis. The author has an hindex of 6, co-authored 9 publications receiving 523 citations.
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Journal ArticleDOI
A DNA topoisomerase VI-like complex initiates meiotic recombination.
Nathalie Vrielynck,Aurélie Chambon,Daniel Vezon,Lucie Pereira,Liudmila Chelysheva,Arnaud De Muyt,Christine Mézard,Claudine Mayer,Claudine Mayer,Claudine Mayer,Mathilde Grelon +10 more
TL;DR: Findings suggest that the catalytic core complex responsible for meiotic DSB formation in eukaryotes adopts a topo VI–like structure.
Journal ArticleDOI
Variation in crossing-over rates across chromosome 4 of Arabidopsis thaliana reveals the presence of meiotic recombination “hot spots”
Jan Drouaud,Christine Camilleri,Pierre-Yves Bourguignon,Aurélie Canaguier,Aurélie Bérard,Daniel Vezon,Sandra Giancola,Dominique Brunel,Vincent Colot,Bernard Prum,Hadi Quesneville,Christine Mézard +11 more
TL;DR: Principal component analysis showed that CO rates negatively correlate with the G+C content, in contrast to that reported in other eukaryotes, and "hot spots" of meiotic recombination contained in small fragments of a few kilobases are revealed.
Journal ArticleDOI
Recombination Rate Heterogeneity within Arabidopsis Disease Resistance Genes.
Kyuha Choi,Carsten Reinhard,Heïdi Serra,Piotr Ziółkowski,Piotr Ziółkowski,Charles J Underwood,Charles J Underwood,Xiaohui Zhao,Thomas J. Hardcastle,Nataliya E. Yelina,Catherine H Griffin,Matthew A. Jackson,Christine Mézard,Gil McVean,Gregory P. Copenhaver,Ian R. Henderson +15 more
TL;DR: It is shown that a subset of NBS-LRR genes are strong hotspots, whereas others are coldspots, which proposes results from varying coevolutionary pressures exerted by host-pathogen relationships, and is influenced by structural heterozygosity.
Journal ArticleDOI
A new light on the meiotic DSB catalytic complex
TL;DR: An overview of the knowledge on TopoVI structure and mode of action is provided and they are compared with their meiotic counterparts to discuss the nature, structure and functions of the meiotic Topo VI-like complex during meiotic DSB formation.
Journal ArticleDOI
A cytological approach to studying meiotic recombination and chromosome dynamics in Arabidopsis thaliana male meiocytes in three dimensions.
Aurélie Hurel,Dylan Phillips,Nathalie Vrielynck,Christine Mézard,Mathilde Grelon,Nicolas Christophorou +5 more
TL;DR: A protocol to preserve the 3D configuration of A. thaliana meiocytes and reveal differential localization behaviors of chromosome ends is set up, showing that the number of telomeres in a bouquet and its volume vary greatly, thus revealing the complexity ofTelomere behavior during meiotic prophase I.