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Christine Mordstein
Researcher at University of Edinburgh
Publications - 10
Citations - 226
Christine Mordstein is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Codon usage bias & Gene expression. The author has an hindex of 5, co-authored 10 publications receiving 103 citations. Previous affiliations of Christine Mordstein include Aarhus University & University of Bath.
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Journal ArticleDOI
Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design.
Alan M. Rice,Atahualpa Castillo Morales,Alexander T Ho,Christine Mordstein,Christine Mordstein,Stephanie Mühlhausen,Semir Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +11 more
TL;DR: An evolutionarily informed approach to attenuation is proposed that, unusually, seeks to increase usage of the already most common synonymous codons in SARS-CoV-2 genes.
Journal ArticleDOI
Codon Usage and Splicing Jointly Influence mRNA Localization.
Christine Mordstein,Rosina Savisaar,Robert Young,Jeanne Bazile,Lana Talmane,Juliet Luft,Michael Liss,Martin S. Taylor,Laurence D. Hurst,Grzegorz Kudla +9 more
TL;DR: It is proposed that splicing promotes the nuclear export of AU-rich mRNAs and that codon- and splicing-dependent effects on expression are under evolutionary pressure in the human genome.
Journal ArticleDOI
A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection.
Martin A M Reijns,Louise Thompson,Juan Carlos Acosta,Holly A. Black,Holly A. Black,Francisco J. Sanchez-Luque,Francisco J. Sanchez-Luque,Austin Diamond,David A. Parry,Alison Daniels,Marie O'Shea,Carolina Uggenti,Maria C. Sanchez,Alan O'Callaghan,Michelle L.L. McNab,Martyna Adamowicz,Elias T. Friman,Toby W. Hurd,Edward J. Jarman,Frederic Li Mow Chee,Jacqueline K. Rainger,Marion F Walker,Camilla Drake,Dasa Longman,Christine Mordstein,Christine Mordstein,Sophie J. Warlow,Stewart McKay,Louise Slater,Morad Ansari,Ian Tomlinson,David Moore,Nadine Wilkinson,Jill Shepherd,Kate Templeton,Ingolfur Johannessen,Christine Tait-Burkard,Jürgen Haas,Nick Gilbert,Ian R. Adams,Andrew P. Jackson +40 more
TL;DR: A multiplex assay using well-established SARS-CoV-2 targets alongside a human cellular control and a viral spike-in control, which monitor sample quality and nucleic acid extraction efficiency, and demonstrates the feasibility of establishing a robust RT-qPCR assay at approximately 10% of the cost of equivalent commercial assays, which could benefit low-resource environments and make high-volume testing affordable.
Journal ArticleDOI
Causes and consequences of purifying selection on SARS-CoV-2.
Atahualpa Castillo Morales,Alan M. Rice,Alexander T Ho,Christine Mordstein,Christine Mordstein,Christine Mordstein,Stefanie Mühlhausen,Samir F Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +12 more
TL;DR: In this article, it was shown that the SARS-CoV-2 mutation rate is at least 49-67% higher than would be estimated based on the rate of appearance of variants in sampled genomes.
Posted ContentDOI
A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection
Martin A M Reijns,Louise Thompson,Juan Carlos Acosta,Holly A. Black,Holly A. Black,Francisco J. Sanchez-Luque,Francisco J. Sanchez-Luque,Austin Diamond,Alison Daniels,Marie O'Shea,Carolina Uggenti,Maria C. Sanchez,Michelle L.L. McNab,Martyna Adamowicz,Elias T. Friman,Toby W. Hurd,Edward J. Jarman,Frederic Li Mow Chee,Jacqueline K. Rainger,Marion F Walker,Camilla Drake,Dasa Longman,Christine Mordstein,Christine Mordstein,Sophie J. Warlow,Stewart McKay,Louise Slater,Morad Ansari,Ian Tomlinson,David Moore,Nadine Wilkinson,Jill Shepherd,Kate Templeton,Ingolfur Johannessen,Christine Tait-Burkard,Jürgen Haas,Nick Gilbert,Ian R. Adams,Andrew P. Jackson +38 more
TL;DR: A multiplex assay using well-established SARS-CoV-2 targets alongside internal controls that monitor sample quality and nucleic acid extraction efficiency is developed and established that this test performs as well as widely used commercial assays, but at substantially reduced cost.