J
Jürgen Haas
Researcher at University of Edinburgh
Publications - 88
Citations - 4929
Jürgen Haas is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 32, co-authored 75 publications receiving 4188 citations. Previous affiliations of Jürgen Haas include Edinburgh Royal Infirmary & Heidelberg University.
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Increased Immune Response Elicited by DNA Vaccination with a Synthetic gp120 Sequence with Optimized Codon Usage
TL;DR: It is reported that optimized codon usage of an injected DNA sequence considerably increases both humoral and cellular immune responses and a synthetic human immunodeficiency virus type 1 gp120 sequence, syngp120, is characterized byrev-independent expression and a low risk of recombination with viral sequences.
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Microbes and Alzheimer's disease
Ruth F. Itzhaki,Ruth F. Itzhaki,Richard Lathe,Brian J. Balin,Melvyn J. Ball,Elaine L. Bearer,Heiko Braak,María J. Bullido,C.J. Carter,Mario Clerici,S. Louise Cosby,Kelly Del Tredici,Hugh J. Field,Tamas Fulop,Claudio Grassi,W. Sue T. Griffin,Jürgen Haas,Alan P. Hudson,Angela R. Kamer,Douglas B. Kell,Federico Licastro,Luc Letenneur,Hugo Lövheim,Roberta Mancuso,Judith Miklossy,Carola Otth,Anna Teresa Palamara,George Perry,Chris M. Preston,Etheresia Pretorius,Timo E. Strandberg,Naji Tabet,Simon D. Taylor-Robinson,Judith A. Whittum-Hudson +33 more
TL;DR: Researchers and clinicians working on Alzheimer’s disease or related topics write to express their concern that one particular aspect of the disease has been neglected.
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The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
Susanne Pfefferle,Julia Schöpf,Manfred Kögl,Caroline C. Friedel,Caroline C. Friedel,Marcel A. Müller,Javier Carbajo-Lozoya,Thorsten Stellberger,Ekatarina von Dall'Armi,Petra Herzog,Stefan Kallies,Daniela Niemeyer,Vanessa Ditt,Thomas Kuri,Roland Züst,Ksenia Pumpor,Rolf Hilgenfeld,Frank Schwarz,Ralf Zimmer,Imke Steffen,Friedemann Weber,Friedemann Weber,Volker Thiel,Georg Herrler,Heinz Jürgen Thiel,Christel Schwegmann-Weßels,Stefan Pöhlmann,Jürgen Haas,Jürgen Haas,Christian Drosten,Albrecht von Brunn +30 more
TL;DR: Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases.
Journal ArticleDOI
The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
Mathieu Blanc,Wei Yuan Hsieh,Kevin A. Robertson,Kai A. Kropp,Thorsten Forster,Guanghou Shui,Paul Lacaze,Steven Watterson,Samantha J. Griffiths,Nathanael J. Spann,Anna Meljon,Simon G. Talbot,Kathiresan Krishnan,Douglas F. Covey,Markus R. Wenk,Marie Craigon,Zsolts Ruzsics,Jürgen Haas,Ana Angulo,William J. Griffiths,Christopher K. Glass,Yuqin Wang,Peter Ghazal +22 more
TL;DR: A cellular antiviral role for macrophage production of 25-hydroxycholesterol as a component of the sterol metabolic network linked to the IFN response via Stat1 is reported, and 25HC is described as a sterol-lipid effector of an innate immune pathway.
Journal ArticleDOI
Cytomegalovirus Recruitment of Cellular Kinases to Dissolve the Nuclear Lamina
TL;DR: The functions of M50/p35, a β-herpesviral protein of murine cytomegalovirus, are reported on, suggesting that herpesviruses target a critical element of nuclear architecture.