J
Juliet Luft
Researcher at University of Edinburgh
Publications - 6
Citations - 102
Juliet Luft is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Nucleotide excision repair. The author has an hindex of 2, co-authored 5 publications receiving 57 citations.
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Journal ArticleDOI
Codon Usage and Splicing Jointly Influence mRNA Localization.
Christine Mordstein,Rosina Savisaar,Robert Young,Jeanne Bazile,Lana Talmane,Juliet Luft,Michael Liss,Martin S. Taylor,Laurence D. Hurst,Grzegorz Kudla +9 more
TL;DR: It is proposed that splicing promotes the nuclear export of AU-rich mRNAs and that codon- and splicing-dependent effects on expression are under evolutionary pressure in the human genome.
Journal ArticleDOI
Pervasive lesion segregation shapes cancer genome evolution
Sarah J. Aitken,Sarah J. Aitken,Craig Anderson,Frances Connor,Oriol Pich,Vasavi Sundaram,Vasavi Sundaram,Christine Feig,Tim F. Rayner,Margus Lukk,Stuart Aitken,Juliet Luft,Elissavet Kentepozidou,Claudia Arnedo-Pac,Sjoerd Viktor Beentjes,Susan E. Davies,Ruben M. Drews,Ailith Ewing,Vera B. Kaiser,Ava Khamseh,Erika López-Arribillaga,Aisling M. Redmond,Javier Santoyo-Lopez,Inés Sentís,Lana Talmane,Andrew D. Yates,Colin A. Semple,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Paul Flicek,Paul Flicek,Duncan T. Odom,Duncan T. Odom,Martin S. Taylor +33 more
TL;DR: It is demonstrated that lesion segregation is a unifying property of exogenous mutagens, including UV light and chemotherapy agents in human cells and tumours, which has profound implications for the evolution and adaptation of cancer genomes.
Posted ContentDOI
Pervasive lesion segregation shapes cancer genome evolution
Sarah J. Aitken,Sarah J. Aitken,Craig Anderson,Frances Connor,Oriol Pich,Vasavi Sundaram,Vasavi Sundaram,Christine Feig,Tim F. Rayner,Margus Lukk,Stuart Aitken,Juliet Luft,Elissavet Kentepozidou,Claudia Arnedo-Pac,Sjoerd Viktor Beentjes,Susan E. Davies,Ruben M. Drews,Ailith Ewing,Vera B. Kaiser,Ava Khamseh,Erika López-Arribillaga,Aisling M. Redmond,Javier Santoyo-Lopez,Inés Sentís,Lana Talmane,Andrew D. Yates,Colin A. Semple,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Paul Flicek,Paul Flicek,Duncan T. Odom,Duncan T. Odom,Martin S. Taylor +33 more
TL;DR: It is demonstrated that lesion segregation is a unifying property of exogenous mutagens, including UV light and chemotherapy agents in human cells and tumours, which has profound implications for the evolution and adaptation of cancer genomes.
Posted ContentDOI
Strand-resolved mutagenicity of DNA damage and repair
C. J. Anderson,Lana Talmane,Juliet Luft,Michael D. Nicholson,John T. Connelly,Oriol Pich,Susan Campbell,Vasavi Sundaram,Frances Connor,Paul A. Ginno,Nuria Lopez-Bigas,Paul Flicek,Colin A. Semple,Duncan T. Odom,Sarah J. Aitken,Martin S. Taylor +15 more
TL;DR: Insight is provided into how strand-asymmetric mechanisms underlie the formation, tolerance, and repair of DNA damage, thereby shaping cancer genome evolution.
Posted ContentDOI
Detecting oncogenic selection through biased allele retention in The Cancer Genome Atlas
TL;DR: Predicting damaging germline variants in genes responsible for the repair of DNA strand breaks and homologous repair as the most common targets of allele biased LOH suggests a ratchet-like process where heterozygous germline mutations in these genes reduce the efficacy of DNA double-strand break repair.