L
Lana Talmane
Researcher at University of Edinburgh
Publications - 9
Citations - 111
Lana Talmane is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 2, co-authored 6 publications receiving 58 citations.
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Journal ArticleDOI
Codon Usage and Splicing Jointly Influence mRNA Localization.
Christine Mordstein,Rosina Savisaar,Robert Young,Jeanne Bazile,Lana Talmane,Juliet Luft,Michael Liss,Martin S. Taylor,Laurence D. Hurst,Grzegorz Kudla +9 more
TL;DR: It is proposed that splicing promotes the nuclear export of AU-rich mRNAs and that codon- and splicing-dependent effects on expression are under evolutionary pressure in the human genome.
Journal ArticleDOI
Pervasive lesion segregation shapes cancer genome evolution
Sarah J. Aitken,Sarah J. Aitken,Craig Anderson,Frances Connor,Oriol Pich,Vasavi Sundaram,Vasavi Sundaram,Christine Feig,Tim F. Rayner,Margus Lukk,Stuart Aitken,Juliet Luft,Elissavet Kentepozidou,Claudia Arnedo-Pac,Sjoerd Viktor Beentjes,Susan E. Davies,Ruben M. Drews,Ailith Ewing,Vera B. Kaiser,Ava Khamseh,Erika López-Arribillaga,Aisling M. Redmond,Javier Santoyo-Lopez,Inés Sentís,Lana Talmane,Andrew D. Yates,Colin A. Semple,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Paul Flicek,Paul Flicek,Duncan T. Odom,Duncan T. Odom,Martin S. Taylor +33 more
TL;DR: It is demonstrated that lesion segregation is a unifying property of exogenous mutagens, including UV light and chemotherapy agents in human cells and tumours, which has profound implications for the evolution and adaptation of cancer genomes.
Posted ContentDOI
Pervasive lesion segregation shapes cancer genome evolution
Sarah J. Aitken,Sarah J. Aitken,Craig Anderson,Frances Connor,Oriol Pich,Vasavi Sundaram,Vasavi Sundaram,Christine Feig,Tim F. Rayner,Margus Lukk,Stuart Aitken,Juliet Luft,Elissavet Kentepozidou,Claudia Arnedo-Pac,Sjoerd Viktor Beentjes,Susan E. Davies,Ruben M. Drews,Ailith Ewing,Vera B. Kaiser,Ava Khamseh,Erika López-Arribillaga,Aisling M. Redmond,Javier Santoyo-Lopez,Inés Sentís,Lana Talmane,Andrew D. Yates,Colin A. Semple,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Paul Flicek,Paul Flicek,Duncan T. Odom,Duncan T. Odom,Martin S. Taylor +33 more
TL;DR: It is demonstrated that lesion segregation is a unifying property of exogenous mutagens, including UV light and chemotherapy agents in human cells and tumours, which has profound implications for the evolution and adaptation of cancer genomes.
Posted ContentDOI
Strand-resolved mutagenicity of DNA damage and repair
C. J. Anderson,Lana Talmane,Juliet Luft,Michael D. Nicholson,John T. Connelly,Oriol Pich,Susan Campbell,Vasavi Sundaram,Frances Connor,Paul A. Ginno,Nuria Lopez-Bigas,Paul Flicek,Colin A. Semple,Duncan T. Odom,Sarah J. Aitken,Martin S. Taylor +15 more
TL;DR: Insight is provided into how strand-asymmetric mechanisms underlie the formation, tolerance, and repair of DNA damage, thereby shaping cancer genome evolution.
Journal ArticleDOI
Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome.
Vera B. Kaiser,Lana Talmane,Yatendra Kumar,Fiona Semple,Marie MacLennan,Deciphering Developmental Disorders Study,David R. FitzPatrick,Martin S. Taylor,Colin A. Semple +8 more
TL;DR: Using ATAC-seq, this article identified transcription factor binding sites (TFBSs) and PRDM9-binding sites, a subset of which will initiate meiotic recombination.