Christine Mordstein

TL;DR: An evolutionarily informed approach to attenuation is proposed that, unusually, seeks to increase usage of the already most common synonymous codons in SARS-CoV-2 genes.

TL;DR: It is proposed that splicing promotes the nuclear export of AU-rich mRNAs and that codon- and splicing-dependent effects on expression are under evolutionary pressure in the human genome.

TL;DR: A multiplex assay using well-established SARS-CoV-2 targets alongside a human cellular control and a viral spike-in control, which monitor sample quality and nucleic acid extraction efficiency, and demonstrates the feasibility of establishing a robust RT-qPCR assay at approximately 10% of the cost of equivalent commercial assays, which could benefit low-resource environments and make high-volume testing affordable.

TL;DR: In this article, it was shown that the SARS-CoV-2 mutation rate is at least 49-67% higher than would be estimated based on the rate of appearance of variants in sampled genomes.

TL;DR: A multiplex assay using well-established SARS-CoV-2 targets alongside internal controls that monitor sample quality and nucleic acid extraction efficiency is developed and established that this test performs as well as widely used commercial assays, but at substantially reduced cost.