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Christine Sedrak
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 4
Citations - 2065
Christine Sedrak is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Antigen & Cancer. The author has an hindex of 4, co-authored 4 publications receiving 1848 citations. Previous affiliations of Christine Sedrak include Stony Brook University.
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Journal ArticleDOI
Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma
Michael A. Postow,Margaret K. Callahan,Margaret K. Callahan,Christopher A. Barker,Christopher A. Barker,Yoshiya Yamada,Yoshiya Yamada,Jianda Yuan,Shigehisa Kitano,Zhenyu Mu,Teresa S. Rasalan,Matthew Adamow,Erika Ritter,Christine Sedrak,Achim A. Jungbluth,Ramon Chua,Arvin Yang,Ruth Ann Roman,Samuel Rosner,Brenna Benson,James P. Allison,Alexander M. Lesokhin,Alexander M. Lesokhin,Sacha Gnjatic,Jedd D. Wolchok,Jedd D. Wolchok,Jedd D. Wolchok +26 more
TL;DR: A case of the abscopal effect is reported in a patient with melanoma treated with ipilimumab and radiotherapy, with temporal associations of tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibodies to other antigens after radiotherapy.
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Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients
Paul Sabbatini,Takemasa Tsuji,Luis Ferran,Erika Ritter,Christine Sedrak,Kevin Tuballes,Achim A. Jungbluth,Gerd Ritter,Carol Aghajanian,Katherine M. Bell-McGuinn,Martee L. Hensley,Jason A. Konner,William P. Tew,David R. Spriggs,Eric W. Hoffman,Ralph Venhaus,Linda Pan,Andres M. Salazar,Catherine M. Diefenbach,Lloyd J. Old,Sacha Gnjatic +20 more
TL;DR: The current study shows that NY-ESO-1 OLP vaccine is safe and rapidly induces consistent integrated immune responses (antibody, CD8+ and CD4+) in nearly all vaccinated patients when given with appropriate adjuvants.
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Clinical Trial of the Intratumoral Administration of Labeled DC Combined With Systemic Chemotherapy for Esophageal Cancer
Shinichi Fujiwara,Hisashi Wada,Hiroshi Miyata,Junji Kawada,Ryohei Kawabata,Hiroyoshi Nishikawa,Sacha Gnjatic,Christine Sedrak,Eiichi Sato,Yurika Nakamura,Mitsuru Sakakibara,Tatsuya Kanto,Eku Shimosegawa,Jun Hatazawa,Tsuyoshi Takahashi,Yukinori Kurokawa,Makoto Yamasaki,Kiyokazu Nakajima,Shuji Takiguchi,Eiichi Nakayama,Masaki Mori,Yuichiro Doki +21 more
TL;DR: The results suggest that the intratumoral administration of 111In-labeled mature DC during chemotherapy does not lead to detectable DC migration from the primary tumor to the draining lymph nodes, and therefore, might not achieve an optimal clinical response.
Journal ArticleDOI
Cancer-testis antigen expression and immunogenicity in AL amyloidosis
Michael Rosenzweig,Heather Landau,David C. Seldin,Carl O'Hara,Saulius Girnius,Nicole Hanson,Denise Frosina,Christine Sedrak,Maria E. Arcila,Raymond L. Comenzo,Sergio Giralt,Sergio Giralt,Sacha Gnjatic,Achim A. Jungbluth,Guenther Koehne,Guenther Koehne +15 more
TL;DR: CT7 is identified as the prevalent CTA in plasma cells of patients with AL amyloidosis, and sero reactivity was observed in individual patients to other CTAs.