C
Christine Vogel
Researcher at New York University
Publications - 125
Citations - 12947
Christine Vogel is an academic researcher from New York University. The author has contributed to research in topics: Gene & Proteomics. The author has an hindex of 40, co-authored 110 publications receiving 11039 citations. Previous affiliations of Christine Vogel include ETH Zurich & Laboratory of Molecular Biology.
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Journal ArticleDOI
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
TL;DR: Current understanding of the major factors regulating protein expression is summarized to demonstrate a substantial role for regulatory processes occurring after mRNA is made in controlling steady-state protein abundances.
Journal ArticleDOI
Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation
TL;DR: Using APEX, it is demonstrated that 73% of the variance in yeast protein abundance is explained by mRNA abundance, with the number of proteins per mRNA log-normally distributed about ∼5,600 (∼540 in E. coli) protein molecules/mRNA.
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Global signatures of protein and mRNA expression levels
TL;DR: This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters.
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Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line
Christine Vogel,Raquel de Sousa Abreu,Daijin Ko,Shu-Yun Le,Bruce A. Shapiro,Suzanne C. Burns,Devraj Sandhu,Daniel R. Boutz,Edward M. Marcotte,Luiz O. F. Penalva +9 more
TL;DR: The absolute protein and mRNA concentration measurements for >1000 human genes described here represent one of the largest datasets currently available, and reveal both general trends and specific examples of post‐transcriptional regulation.
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Evolution of the Protein Repertoire
TL;DR: Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.