C
Christophe Chassagnole
Researcher at Centre national de la recherche scientifique
Publications - 23
Citations - 1044
Christophe Chassagnole is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Flux (metabolism) & Threonine. The author has an hindex of 11, co-authored 20 publications receiving 992 citations. Previous affiliations of Christophe Chassagnole include University of Stuttgart & University of Dundee.
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Journal ArticleDOI
Dynamic modeling of the central carbon metabolism of Escherichia coli.
TL;DR: This work presents a dynamic model, which, for the first time, links the sugar transport system (i.e., phosphotransferase system [PTS]) with the reactions of glycolysis and the pentose-phosphate pathway, and offers the possibility of studying important questions regarding the stability and control of metabolic fluxes.
Journal ArticleDOI
Rational design of a Corynebacterium glutamicum pantothenate production strain and its characterization by metabolic flux analysis and genome-wide transcriptional profiling.
Andrea T. Hüser,Christophe Chassagnole,Nic D. Lindley,Muriel Merkamm,Armel Guyonvarch,Veronika Elišáková,Miroslav Pátek,Jörn Kalinowski,Iris Brune,Alfred Pühler,Andreas Tauch +10 more
TL;DR: The strategy not only successfully improved pantothenate production by genetically modified C. glutamicum strains but also revealed new constraints in attaining high productivity.
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An integrated study of threonine-pathway enzyme kinetics in Escherichia coli.
TL;DR: The simplest rate equations that describe the salient features of the enzymes in the physiological range of metabolite concentrations were derived in order to incorporate them ultimately into a complete model of the threonine pathway, able to predict quantitatively the behaviour of the pathway under natural or engineered conditions.
Journal ArticleDOI
Control of the threonine-synthesis pathway in Escherichia coli: a theoretical and experimental approach
Christophe Chassagnole,David A. Fell,David A. Fell,Badr Raïs,Bernard Kudla,Jean-Pierre Mazat +5 more
TL;DR: The model successfully simulates the main features of the time courses of threonine synthesis previously observed in a cell-free extract without alteration of the experimentally determined parameters, although improved quantitative fits can be obtained with small parameter adjustments.
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Ketopantoate reductase activity is only encoded by ilvC in Corynebacterium glutamicum.
TL;DR: In this article, the Corynebacterium glutamicum ilvC gene is able to complement a ketopantoate reductase deficient Escherichia coli mutant.