P
Pierre J. Courtoy
Researcher at Université catholique de Louvain
Publications - 244
Citations - 13509
Pierre J. Courtoy is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Endocytosis & Endosome. The author has an hindex of 64, co-authored 244 publications receiving 12677 citations. Previous affiliations of Pierre J. Courtoy include French Institute of Health and Medical Research & Massachusetts Institute of Technology.
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Journal ArticleDOI
Cell-mediated Extracellular Acidification and Bone-resorption - Evidence for a Low Ph in Resorbing Lacunae and Localization of a 100-kd Lysosomal Membrane-protein At the Osteoclast Ruffled Border
TL;DR: Lysosomal enzymes are also directionally secreted by the osteoclast into the acidified extracellular compartment which can therefore be considered as the functional equivalent of a secondary lysosome with a low pH, acid hydrolases, the substrate, and a limiting membrane containing the 100-kD antigen.
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Control of liver cell fate decision by a gradient of TGFβ signaling modulated by Onecut transcription factors
Frédéric Clotman,Patrick Jacquemin,Nicolas Plumb-Rudewiez,Christophe E. Pierreux,Patrick Van Der Smissen,Harry C. Dietz,Pierre J. Courtoy,Guy G. Rousseau,Frédéric P. Lemaigre +8 more
TL;DR: A gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages.
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Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.
Erik Ilsø Christensen,Olivier Devuyst,Geneviève Dom,Rikke Nielsen,Patrick Van Der Smissen,Pierre J. Verroust,Michèle Leruth,William B. Guggino,Pierre J. Courtoy +8 more
TL;DR: Impaired protein endocytosis caused by invalidation of ClC-5 primarily reflects a trafficking defect of megalin and cubilin in PTC.
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Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
Fadel Tissir,Yibo Qu,Mireille Montcouquiol,Libing Zhou,Kouji Komatsu,Dongbo Shi,Toshihiko Fujimori,Jason Labeau,Donatienne Tyteca,Pierre J. Courtoy,Yves Poumay,Tadashi Uemura,André M. Goffinet +12 more
TL;DR: The findings suggest that planar cell polarity signaling is involved in ependymal cilia development and in the pathophysiology of hydrocephalus, with possible implications in other ciliopathies.
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Mice lacking renal chloride channel, CLC-5, are a model for Dent’s disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis
Sha Sha Wang,Olivier Devuyst,Pierre J. Courtoy,Xi Tao Wang,Hua Wang,Yanshu Wang,Rajesh V. Thakker,Sandra E. Guggino,William B. Guggino +8 more
TL;DR: CLC-5-deficient mice provide a model for Dent's disease and this will help in elucidating the function of this chloride channel in endocytosis and renal calcium homeostasis, as well as demonstrating a role for C LC-5 in endosomal uptake of low molecular weight proteins.