N
Nicolas Plumb-Rudewiez
Researcher at Université catholique de Louvain
Publications - 5
Citations - 505
Nicolas Plumb-Rudewiez is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Transcription factor & Hepatocyte Nuclear Factor 6. The author has an hindex of 5, co-authored 5 publications receiving 478 citations. Previous affiliations of Nicolas Plumb-Rudewiez include Catholic University of Leuven.
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Journal ArticleDOI
Control of liver cell fate decision by a gradient of TGFβ signaling modulated by Onecut transcription factors
Frédéric Clotman,Patrick Jacquemin,Nicolas Plumb-Rudewiez,Christophe E. Pierreux,Patrick Van Der Smissen,Harry C. Dietz,Pierre J. Courtoy,Guy G. Rousseau,Frédéric P. Lemaigre +8 more
TL;DR: A gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages.
Journal ArticleDOI
Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6
Randolph P. Matthews,Nicolas Plumb-Rudewiez,Kristin Lorent,Paul Gissen,Colin A. Johnson,Frédéric P. Lemaigre,Michael Pack +6 more
TL;DR: Findings identify vps33b as a novel downstream target gene of the hnf6/vhnf1 pathway that regulates bile duct development in zebrafish and show that tissue-specific roles for genes that regulate trafficking of intracellular proteins have been modified during vertebrate evolution.
Journal ArticleDOI
Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development.
Jean-Bernard Beaudry,Christophe E. Pierreux,Graham P. Hayhurst,Nicolas Plumb-Rudewiez,Mary C. Weiss,Guy G. Rousseau,Frédéric P. Lemaigre +6 more
TL;DR: The observations on the regulation of g6pc by HNF-6 provide a model whereby synergism, interdependency, and threshold concentrations of LETFs and coactivators determine time-specific expression of genes during liver development.
Journal ArticleDOI
Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver.
Nicolas Plumb-Rudewiez,Frédéric Clotman,Helene Strick-Marchand,Christophe E. Pierreux,Mary C. Weiss,Guy G. Rousseau,Frédéric P. Lemaigre +6 more
TL;DR: It is concluded that HNF‐6 inhibits Foxa1 by inhibiting the activity of the TGF‐β signaling pathway, identifying a new mechanism of interaction between liver‐enriched transcription factors whereby one factor indirectly controls another by modulating theActivity of a signaling pathway.
Journal ArticleDOI
Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf-6: 65
Randolph P. Matthews,Nicolas Plumb-Rudewiez,Kristin Lorent,Paul Gissen,Colin A. Johnson,Frédéric P. Lemaigre,Michael Pack +6 more
TL;DR: Findings identify vps33b as a novel downstream target gene of the hnf6/vhnf1 pathway that regulates bile duct development in zebrafish and show that tissue-specific roles for genes that regulate trafficking of intracellular proteins have been modified during vertebrate evolution.